Vertebral Osteomyelitis After Spine Surgery
| Autor: | Kathrin Kuhr, Lena M Biehl, Harald Seifert, Ayla Yagdiran, Marianne Breuninger, Rolf Sobottke, Anja Willinger, Jan Siewe, Norma Jung, Clara Lehmann, Gerd Fätkenheuer, Christina Otto-Lambertz |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Comorbidity Cohort Studies Young Adult 03 medical and health sciences Postoperative Complications 0302 clinical medicine Internal medicine medicine Humans Vertebral osteomyelitis Disease Orthopedics and Sports Medicine Prospective Studies Prospective cohort study Aged Retrospective Studies 030222 orthopedics Bacteria Proportional hazards model business.industry Hazard ratio Osteomyelitis Retrospective cohort study Middle Aged medicine.disease Spine Cohort Female Neurology (clinical) business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Spine. 45:1426-1434 |
| ISSN: | 1528-1159 0362-2436 |
| DOI: | 10.1097/brs.0000000000003542 |
| Popis: | STUDY DESIGN Prospective cohort study. OBJECTIVE We aimed to determine the 2-year survival and to identify clinical and microbiological characteristics of patients with native vertebral osteomyelitis (VO) as compared to postoperative VO to find further strategies for improvement of the management of VO. SUMMARY OF BACKGROUND DATA A relevant subgroup (20%-30%) of patients with VO has a history of spine surgery. Infection in these patients might be clinically different from native VO. However, clinical, microbiological, and outcome characteristics of this disease entity have not been well studied as most trials either excluded these patients or are limited by a small cohort and short observation period. METHODS Between 2008 and 2013, patients who presented at a tertiary care center with symptoms and imaging findings suggestive of VO were reviewed by specialists in infectious diseases, clinical microbiology, and orthopedics to confirm the diagnosis and followed prospectively for a period of 2 years. Statistical analysis for group comparisons, survival analysis, and uni- and multivariable Cox regression models were performed. RESULTS Thirty percent of the patients with VO (56/189) reported a history of spine surgery in the same segment. Patients with postoperative infection had a lower ASA score (American Society of Anesthesiologists) (P = 0.01) and were less likely to suffer from comorbidities compared to native cases (P = 0.003). Infections caused by coagulase-negative staphylococci (33.3 vs. 6.5%, P |
| Databáze: | OpenAIRE |
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