Effects of increasing sevoflurane MAC levels on mid-latency auditory evoked potentials in infants, schoolchildren, and the elderly
| Autor: | G. E. H. Kuhnle, Cyrill Hornuss, Hans-Helge Müller, V. Edelmann-Gahr, G. Flake, M. Daunderer, Matthias Feuerecker, D. Wiepcke, M. Lenk |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Methyl Ethers Adolescent Anesthesia General Sevoflurane Cohort Studies Sufentanil Reaction Time Humans Medicine Elderly people General anaesthesia Wakefulness Latency (engineering) Child Aged Aged 80 and over Hypnotic Effects Analysis of Variance School age child Dose-Response Relationship Drug business.industry Age Factors Infant Anesthesiology and Pain Medicine Child Preschool Anesthesia Anesthetics Inhalation Evoked Potentials Auditory Female Analysis of variance business medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 107:726-734 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/aer226 |
| Popis: | Background Detection of mid-latency auditory evoked potentials (MLAEPs) is a technology to monitor central nervous structures. As seen in adults and children, general anaesthesia influences the MLAEP latencies. MLAEP detection seems to be a promising tool to assess different levels of anaesthesia depth in adults and children. Methods MLAEPs were recorded in 10 infants (2 months–3 yr), 12 schoolchildren (6–14 yr), and 10 elderly (75–89 yr) under general anaesthesia with increasing concentrations of sevoflurane at steady state. In addition, MLAEPs were detected before and after the application of sufentanil. Results At all different ages, MLAEP latencies increased significantly with higher volume percentages of sevoflurane. These results were also detectable when MAC values of sevoflurane were compared with MLAEP peaks. An age-dependent effect could be displayed as elderly people need lower absolute sevoflurane concentrations to achieve the same MLAEP peak increase. Overall, the application of sufentanil under steady-state sevoflurane application at 1 MAC did not importantly affect the MLAEP latencies. Conclusions MLAEP latencies increase at the influence of sevoflurane in a dose-dependent manner and in relation to age. These results imply that MLAEP detection is a reasonable tool for monitoring hypnotic effects at all ages. Further studies are required to standardize MLAEP alterations related to effects of medication used for general anaesthesia at all different ages. |
| Databáze: | OpenAIRE |
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