The Effect of Tamoxifen and Fluoride on Bone Mineral Density, Biomechanical Properties and Blood Lipids in Ovariectomized Rats
| Autor: | Andrzej Pawlik, Zofia Myśliwiec, Bogusław Czerny, Zygmunt Juzyszyn |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Ovariectomy Health Toxicology and Mutagenesis Blood lipids Toxicology Bone tissue Bone and Bones Bone remodeling chemistry.chemical_compound Bone Density Internal medicine medicine Animals Rats Wistar Pharmacology Bone mineral Lumbar Vertebrae Dose-Response Relationship Drug Cholesterol Body Weight Cholesterol HDL Uterus Estrogen Antagonists Lipid metabolism Cholesterol LDL Organ Size Antiestrogen Rats Tamoxifen medicine.anatomical_structure Endocrinology chemistry Ovariectomized rat Sodium Fluoride Female lipids (amino acids peptides and proteins) |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1600-0773 0901-9928 |
| Popis: | The most important aspect of therapy with fluoride and tamoxifen concerns its influence on bone tissue and lipid metabolism. The aim of the study was to evaluate the effect of tamoxifen and natrium fluoride (NaF) on bone metabolism, biochemical properties and blood lipids levels in ovariectomized rats. The study was performed in Wistar rats divided into 5 subgroups: ovariectomized controls, rats treated with NaF 20 mg/kg/24 hr, rats treated with NaF 20 mg/kg/24 hr+tamoxifen 2 mg/kg/24 hr, rats treated with NaF 20 mg/kg/24 hr plus tamoxifen 4 mg/kg/24 hr, and sham-operated controls. In ovariectomized rats the increase of total cholesterol, low-density lipoproteins cholesterol (LDL-cholesterol) as well as the decrease of bone mineral content, bone mineral density and biomechanical properties was observed. The therapy with NaF increased the level of total cholesterol, LDL-cholesterol, triglycerides, bone mineral density, bone mineral content. In this group the decrease of bone strength and stiffness was observed. The administration of tamoxifen reduced the changes in plasma lipid levels, but did not improve the biomechanical properties of bone tissue. |
| Databáze: | OpenAIRE |
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