Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy—6-month MRI follow-up after experimental traumatic brain injury
| Autor: | Riikka Immonen, Asla Pitkänen, Amna Yasmin, Olli Gröhn, Tomi Paananen, Pedro Andrade |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Histology Traumatic brain injury Iron Heme Epileptogenesis Lesion 03 medical and health sciences 0302 clinical medicine Atrophy Idiopathic normal pressure hydrocephalus Seizures Brain Injuries Traumatic Animals Medicine 030304 developmental biology 0303 health sciences business.industry General Neuroscience medicine.disease Magnetic Resonance Imaging Rats 3. Good health Hydrocephalus Disease Models Animal medicine.anatomical_structure Ventricle Ventriculomegaly Choroid Plexus Original Article Choroid plexus Brain–CSF barrier Anatomy medicine.symptom business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Brain Structure & Function |
| ISSN: | 1863-2661 1863-2653 |
| DOI: | 10.1007/s00429-021-02395-5 |
| Popis: | Ventricular enlargement is one long-term consequence of a traumatic brain injury, and a risk factor for memory disorders and epilepsy. One underlying mechanisms of the chronic ventricular enlargement is disturbed cerebrospinal-fluid secretion or absorption by choroid plexus. We set out to characterize the different aspects of ventricular enlargement in lateral fluid percussion injury (FPI) rat model by magnetic resonance imaging (MRI) and discovered choroid plexus injury in rats that later developed hydrocephalus. We followed the brain pathology progression for 6 months and studied how the ventricular growth was associated with the choroid plexus injury, cortical lesion expansion, hemorrhagic load or blood perfusion deficits. We correlated MRI findings with the seizure susceptibility in pentylenetetrazol challenge and memory function in Morris water-maze. Choroid plexus injury was validated by ferric iron (Prussian blue) and cytoarchitecture (Nissl) stainings. We discovered choroid plexus injury that accumulates iron in 90% of FPI rats by MRI. The amount of the choroid plexus iron remained unaltered 1-, 3- and 6-month post-injury. During this time, the ventricles kept on growing bilaterally. Ventricular growth did not depend on the cortical lesion severity or the cortical hemorrhagic load suggesting a separate pathology. Instead, the results indicate choroidal injury as one driver of the post-traumatic hydrocephalus, since the higher the choroid plexus iron load the larger were the ventricles at 6 months. The ventricle size or the choroid plexus iron load did not associate with seizure susceptibility. Cortical hypoperfusion and memory deficits were worse in rats with greater ventricular growth. Supplementary Information The online version contains supplementary material available at 10.1007/s00429-021-02395-5. |
| Databáze: | OpenAIRE |
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