Personalized gene-diet study of rs2239670 gene variants and dietary patterns among obese adults

Autor: Mahdieh Khodarahmi, Mahdieh Abbasalizad Farhangi, Mahdi Niknam
Rok vydání: 2022
Předmět:
Zdroj: Clinical Nutrition ESPEN. 47:358-366
ISSN: 2405-4577
DOI: 10.1016/j.clnesp.2021.11.010
Popis: Summary Objective The aim of the present study was to assess the interaction of major dietary patterns with Cocaine- and Amphetamine-Regulated Transcript (CART) prepropeptide gene rs2239670 variant in apparently healthy obese Iranians. Methods A total of 288 apparently healthy obese participants aged 20-50 years were recruited in this cross-sectional study. Usual dietary intake was assessed using a 147-item semi-quantitative validated food frequency questionnaire. Genotyping of the CART gene rs2239670 polymorphism was conducted by the polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP). Results The results showed that the majority of the participants had GG genotype (65.4%). Three dietary patterns were extracted: prudent dietary pattern (PDP), legume dietary pattern (LDP), and mixed dietary pattern (MDP). There were significant interactions between PDP and rs2239670 variant on fat free mass (FFM) (p Interaction = 0.039), basal metabolic rate (BMR) (p Interaction = 0.039). Also, significant interactions were observed between LDP and rs2239670 polymorphism on the diastolic blood pressure (DBP) (p Interaction = 0.026), waist to hip ratio (WHR) (p Interaction = 0.050), agouti-related protein (AgRP) (p Interaction = 0.012), and α-melanocyte stimulating hormone (α-MSH) (p Interaction =0.006). Conclusions The CART rs2239670 SNP interacts with dietary patterns to affect some of the cardio-metabolic risk factors.
Databáze: OpenAIRE
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