Dual imaging-guided photothermal/photodynamic therapy using micelles
| Autor: | Xiaoyong Wang, Qiaoli Peng, Huajian Mao, Gang Liu, Huabing Chen, Hong Yang, Miao Guo, Hui He, Cuicui Ge, Aijun Zhu, Yanli Li, Xiaoyuan Chen, Xin Tian, Xiangliang Yang, Yangyun Wang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Materials science
Cell Survival medicine.medical_treatment Biophysics Mice Nude Photoacoustic imaging in biomedicine Bioengineering Photodynamic therapy Micelle Article Photoacoustic Techniques Biomaterials Mice chemistry.chemical_compound Cell Line Tumor Neoplasms medicine Animals Photosensitizer Doxorubicin Coloring Agents Micelles Mice Inbred BALB C Photosensitizing Agents Optical Imaging Carbocyanines Photothermal therapy Photochemotherapy chemistry Mechanics of Materials Cancer cell Ceramics and Composites Female Gold Indocyanine green Biomedical engineering medicine.drug |
| Zdroj: | Biomaterials. 35:4656-4666 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2014.02.018 |
| Popis: | We report a type of photosensitizer (PS)-loaded micelles integrating cyanine dye as potential theranostic micelles for precise anatomical tumor localization via dual photoacoustic (PA)/near-infrared fluorescent (NIRF) imaging modalities, and simultaneously superior cancer therapy via sequential synergistic photothermal therapy (PTT)/photodynamic therapy (PDT). The micelles exhibit enhanced photostability, cell internalization and tumor accumulation. The dual NIRF/PA imaging modalities of the micelles cause the high imaging contrast and spatial resolution of tumors, which provide precise anatomical localization of the tumor and its inner vasculature for guiding PTT/PDT treatments. Moreover, the micelles can generate severe photothermal damage on cancer cells and destabilization of the lysosomes upon PTT photo-irradiation, which subsequently facilitate synergistic photodynamic injury via PS under PDT treatment. The sequential treatments of PTT/PDT trigger the enhanced cytoplasmic delivery of PS, which contributes to the synergistic anticancer efficacy of PS. Our strategy provides a dual-modal cancer imaging with high imaging contrast and spatial resolution, and subsequent therapeutic synergy of PTT/PDT for potential multimodal theranostic application. |
| Databáze: | OpenAIRE |
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