Mechanisms by which angiotensin II affects the heart rate of the conscious sheep
| Autor: | Warwick B. Lee, Eugenie R. Lumbers, Mansel J. Ismay |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
Nitroprusside Tachycardia medicine.medical_specialty Baroreceptor Physiology Blood Pressure Propranolol Heart Rate Internal medicine Renin–angiotensin system Animals Medicine Infusions Parenteral Pulse Sheep Angiotensin II receptor type 1 Dose-Response Relationship Drug biology business.industry Angiotensin II Parasympatholytics Angiotensin-converting enzyme Endocrinology Blood pressure Sympatholytics biology.protein Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Circulation Research. 47:286-292 |
| ISSN: | 1524-4571 0009-7330 |
| DOI: | 10.1161/01.res.47.2.286 |
| Popis: | Intravenous infusions of angiotensin II were given to conscious sheep. During these infusions, the pressor action of angiotensin was antagonized by concomitant infusion of sodium nitroprusside. Under these conditions, angiotensin produced a dose-dependent tachycardia. This dose-dependent tachycardia was not affected by propranolol and therefore it was not due to an action of angiotensin on sympathoadrenal mechanisms. The dose-dependent tachycardia was reduced by atropine, and abolished by increases in systolic pressure. We conclude that iv infusions of angiotensin cause a central, dose-dependent reduction in vagal tone. This action is normally antagonized by the baroreceptor reflex response to the hypertensive action of angiotensin. Therefore, in those conditions in which endogenous angiotensin production is increased and blood pressure is not elevated (e.g., sodium deficiency and pregnancy), angiotensin may influence heart rate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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