Associations of B cell-activating factor (BAFF) and anti-BAFF autoantibodies with disease activity in multi-ethnic Asian systemic lupus erythematosus patients in Singapore

Autor:	Bernard P. Leung, Hwee Siew Howe, K S S Tay, W G Law, K O Kong, Bernard Yu-Hor Thong, T Y Lian, E T Koh, Tang Ching Lau, F L Chia, H H Chng
Rok vydání:	2017
Předmět:	0301 basic medicine Adult Male Immunology Enzyme-Linked Immunosorbent Assay Disease G Antibody Disease activity 03 medical and health sciences 0302 clinical medicine stomatognathic system Asian People immune system diseases Limit of Detection B-Cell Activating Factor Immunology and Allergy Medicine Humans Lupus Erythematosus Systemic B-cell activating factor skin and connective tissue diseases Autoantibodies 030203 arthritis & rheumatology Singapore biology business.industry Autoantibody Original Articles Middle Aged Pathophysiology stomatognathic diseases 030104 developmental biology Immunoglobulin G Cohort biology.protein Female Antibody business
Zdroj:	Clinical and experimental immunology. 189(3)
ISSN:	1365-2249
Popis:	Summary To measure the levels of B cell-activating factor (BAFF) and endogenous anti-BAFF autoantibodies in a cohort of multi-ethnic Asian systemic lupus erythematosus (SLE) patients in Singapore, to determine their correlation with disease activity. Serum samples from 121 SLE patients and 24 age- and sex-matched healthy controls were assayed for BAFF and anti-BAFF immunoglobulin (Ig)G antibody levels by enzyme-linked immunosorbent assay (ELISA). The lowest reliable detection limit for anti-BAFF-IgG antibody levels was defined as 2 standard deviations (s.d.) from blank. Correlation of serum BAFF and anti-BAFF IgG levels with disease activity [scored by SLE Activity Measure revised (SLAM-R)], and disease manifestations were determined in these 121 patients. SLE patients had elevated BAFF levels compared to controls; mean 820 ± 40 pg/ml and 152 pg ± 45/ml, respectively [mean ± standard error of the mean (s.e.m.), P < 0·01], which were correlated positively with anti-dsDNA antibody levels (r = 0·253, P < 0·03), and SLAM-R scores (r = 0·627, P < 0·01). In addition, SLE patients had significantly higher levels of anti-BAFF IgG, which were correlated negatively with disease activity (r = –0·436, P < 0·01), levels of anti-dsDNA antibody (r = –0·347, P
Databáze:	OpenAIRE
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