Normal ranges for fetal electrocardiogram values for the healthy fetus of 18-24 weeks of gestation: a prospective cohort study
| Autor: | S. Guid Oei, Carlijn Lempersz, Tammo Delhaas, Christian Schroer, Joeh Judith van Laar, Rik Vullings, Kmj Kim Verdurmen |
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| Přispěvatelé: | MUMC+: MA Arts Assistenten Obstetrie Gynaecologie (9), Biomedische Technologie, RS: CARIM - R2.09 - Cardiovascular system dynamics, Signal Processing Systems, Eindhoven MedTech Innovation Center, Biomedical Diagnostics Lab |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Heart Defects Congenital medicine.medical_specialty Heart disease Gestational Age 030204 cardiovascular system & hematology Ultrasonography Prenatal 03 medical and health sciences Study Protocol Electrocardiography 0302 clinical medicine Fetal Heart Pregnancy Reference Values Internal medicine Obstetrics and Gynaecology medicine Humans Prospective Studies Fetal electrocardiography Prospective cohort study Congenital heart disease Fetus 030219 obstetrics & reproductive medicine Obstetrics business.industry Obstetrics and Gynecology medicine.disease 3. Good health Fetal circulation Cardiac nerve In utero embryonic structures Cardiology Gestation Female business Fetal electrocardiogram parameters |
| Zdroj: | BMC Pregnancy and Childbirth BMC Pregnancy and Childbirth, 16:227. BioMed Central Ltd BMC Pregnancy and Childbirth, 16(2):227. BioMed Central |
| ISSN: | 1471-2393 |
| Popis: | BackgroundThe fetal anomaly ultrasound only detects 65 to 81 % of the patients with congenital heart disease, making it the most common structural fetal anomaly of which a significant part is missed during prenatal life. Therefore, we need a reliable non-invasive diagnostic method which improves the predictive value for congenital heart diseases early in pregnancy. Fetal electrocardiography could be this desired diagnostic method. There are multiple technical challenges to overcome in the conduction of the fetal electrocardiogram. In addition, interpretation is difficult due to the organisation of the fetal circulation in utero. We want to establish the normal ranges and values of the fetal electrocardiogram parameters in healthy fetuses of 18 to 24 weeks of gestation.Methods/DesignWomen with an uneventful singleton pregnancy between 18 and 24 weeks of gestation are asked to participate in this prospective cohort study. A certified and experienced sonographist performs the fetal anomaly scan. Subsequently, a fetal electrocardiogram recording is performed using dedicated signal processing methods. Measurements are performed at two institutes. We will include 300 participants to determine the normal values and 95 % confidence intervals of the fetal electrocardiogram parameters in a healthy fetus. We will evaluate the fetal heart rate, segment intervals, normalised amplitude and the fetal heart axis. Three months postpartum, we will evaluate if a newborn is healthy through a questionnaire.DiscussionFetal electrocardiography could be a promising tool in the screening program for congenital heart diseases. The electrocardiogram is a depiction of the intimate relationship between the cardiac nerve conduction pathways and the structural morphology of the fetal heart, and therefore particularly suitable for the detection of secondary effects due to a congenital heart disease (hypotrophy, hypertrophy and conduction interruption). |
| Databáze: | OpenAIRE |
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