Critical issues in translational and clinical research for the study of new technologies to enhance bone repair
| Autor: | Jörg, Goldhahn, Bruce, Mitlak, Per, Aspenberg, John A, Kanis, René, Rizzoli, Jean-Yves, Reginster, Michael, Wagener |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Fracture Healing/drug effects/physiology medicine.medical_specialty Emerging technologies media_common.quotation_subject Osteoporosis Harmonization Osteoporosis/complications Bone healing Indirect costs Fractures Bone Quality of life (healthcare) medicine Fractures Bone/etiology/physiopathology/therapy Humans Orthopedics and Sports Medicine Intensive care medicine Function (engineering) media_common Fracture Healing business.industry General Medicine medicine.disease United States Surgery Europe Clinical research ddc:618.97 Practice Guidelines as Topic Quality of Life Female business |
| Zdroj: | Journal of Bone and Joint Surgery. American Volume, Vol. 90 Suppl 1 (2008) pp. 43-47 |
| ISSN: | 1535-1386 0021-9355 |
| Popis: | Osteoporosis increases fracture risk, especially in metaphyseal bone. Fractures seriously impair function and quality of life and incur large direct and indirect costs. Although the prevention of fractures is certainly the option, a fast and uneventful healing process is optimal when fractures do occur. Many new therapeutic strategies have been developed to accelerate fracture-healing or to diminish the complication rate during the course of fracture-healing. However, widely accepted guidelines are needed to demonstrate the positive or negative interactions of bioactive substances, drugs, and other agents that are being used to promote fracture-healing. For each study design, the primary study goal should be indicated. Outcome variables should include both objective and subjective parameters. The guidelines should be harmonized between European and American regulatory authorities to ensure comparability of results of studies and to foster global harmonization of regulatory requirements. |
| Databáze: | OpenAIRE |
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