Hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice
| Autor: | Niharika Mandal, Mahaboobkhan Rasool, Evan Prince Sabina, Smita Patel, Jaisy Samuel, Pranatharthiharan Preety, Punya Pallabi Mishra, Segu R. Ramya |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Antioxidant medicine.medical_treatment Glutathione reductase Pharmaceutical Science Aspartate transaminase Pharmacology Antioxidants Lipid peroxidation Magnoliopsida Mice chemistry.chemical_compound Gallic Acid medicine Animals Gallic acid Acetaminophen chemistry.chemical_classification biology Plant Extracts Tumor Necrosis Factor-alpha Glutathione peroxidase Glutathione Liver Biochemistry chemistry Alanine transaminase biology.protein Lipid Peroxidation Chemical and Drug Induced Liver Injury Phytotherapy |
| Zdroj: | Journal of Pharmacy and Pharmacology. 62:638-643 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1211/jpp.62.05.0012 |
| Popis: | Objectives The aim of this research paper was to investigate the hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice. Methods In the present study, the hepatoprotective and antioxidant effects of gallic acid were evaluated against paracetamol-induced hepatotoxicity in mice and compared with the silymarin, a standard hepatoprotective drug. The mice received a single dose of paracetamol (900 mg/kg body weight i.p.). Gallic acid (100 mg/kg body weight i.p.) and silymarin (25 mg/kg body weight i.p.) were administered 30 min after the injection of paracetamol. After 4 h, liver marker enzymes (aspartate transaminase, alanine transaminase and alkaline phosphatase) and inflammatory mediator tumour necrosis factor-alpha (TNF-α) were estimated in serum, while the lipid peroxidation and antioxidant status (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glutathione) were determined in liver homogenate of the control and experimental mice. Key findings Increased activities of liver marker enzymes and elevated TNF-α and lipid peroxidation levels were observed in mice exposed to paracetamol (P < 0.05), whereas the antioxidant status was found to be depleted (P < 0.05) when compared with the control group. However gallic acid treatment (100 mg/kg body weight i.p.) significantly reverses (P < 0.05) the above changes by its antioxidant action compared to the control group as observed in the paracetamol-challenged mice. Conclusions The results clearly demonstrate that gallic acid possesses promising hepatoprotective effects. |
| Databáze: | OpenAIRE |
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