Fas and FasL expression in the spinal cord following cord hemisection in the monkey
| Autor: | Liu Jia, Zhou Xin-Fu, Xiyang Yanbin, Zou Yu, Li Hui, Guan Yu-Guang, Wang Ting-Hua, Zhan Xi, Wang Jun, Hen Xin-Hua, You Chao |
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| Přispěvatelé: | Jia, Liu, Yu, Zou, Hui, Li, Yu-Guang, Guan, Zhou, Xin-Fu, Chao, You, Yanbin, Xiyang, Xi, Zhan, Jun, Wang, Xin-Hua, Hen, Ting-Hua, Wang |
| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology medicine.medical_specialty Cord Fas Ligand Protein Apoptosis Motor Activity Biochemistry Fas ligand Cellular and Molecular Neuroscience Hemisection Neuroplasticity medicine In Situ Nick-End Labeling Animals fas Receptor Spinal cord injury Spinal Cord Injuries Fas/FasL business.industry Motor Cortex Precentral gyrus spinal cord General Medicine Anatomy Spinal cord medicine.disease Macaca mulatta precentral gyrus Hindlimb medicine.anatomical_structure Spinal Cord immunohistochemistry Rhesus monkey business Motor cortex |
| Zdroj: | Neurochemical research. 36(3) |
| ISSN: | 1573-6903 |
| Popis: | The changes of endogenous Fas/FasL in injured spinal cord, mostly in primates, are not well known. In this study, we investigated the temporal changes in the expression of Fas and FasL and explored their possible roles in the ventral horn of the spinal cord and associated precentral gyrus following T11 spinal cord hemisection in the adult rhesus monkey. A significant functional improvement was seen with the time going on in monkeys subjected to cord hemisection. Apoptotic cells were also seen in the ventral horn of injured spinal cord with TUNEL staining, and a marked increase presents at 7 days post operation (dpo). Simultaneously, the number of Fas and FasL immunoreactive neurons in the spinal cords caudal and rostral to injury site and their intracellular optical density (OD) in the ipsilateral side of injury site at 7 dpo increased significantly more than that of control group and contralateral sides. This was followed by a decrease and returned to normal level at 60 dpo. No positive neurons were observed in precentral gyrus. The present results may provide some insights to understand the role of Fas/FasL in the spinal cord but not motor cortex with neuronal apoptosis and neuroplasticity in monkeys subjected to hemisection spinal cord injury. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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