Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity
| Autor: | Kine Eide Kvitne, Veronica Krogstad, Christine Wegler, Line Kristin Johnson, Marianne K. Kringen, Markus Herberg Hovd, Jens K. Hertel, Maria Heijer, Rune Sandbu, Eva Skovlund, Per Artursson, Cecilia Karlsson, Shalini Andersson, Tommy B. Andersson, Jøran Hjelmesæth, Anders Åsberg, Rasmus Jansson‐Löfmark, Hege Christensen, Ida Robertsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Pharmacology
obesity Drug metabolisms cytochrome P450 Gastric Bypass Pharmacology and Toxicology Farmakologi och toxikologi Farmaceutiska vetenskaper drug metabolism Obesity Morbid Cytochrome P-450 CYP2C19 Pharmaceutical Sciences Gastric bypasses Cytochrome P-450 CYP1A2 Weight Loss Humans Pharmacology (medical) Obesity gastric bypass pharmacokinetics Caloric Restriction Cytochrome P-450 CYP2C9 |
| Zdroj: | British Journal of Clinical Pharmacology |
| ISSN: | 0306-5251 |
| Popis: | Aim: Roux-en-Y gastric bypass (RYGB) may influence drug disposition due to surgery-induced gastrointestinal alterations and/or subsequent weight loss. The objective was to compare short- and long-term effects of RYGB and diet on the metabolic ratios of paraxanthine/caffeine (cytochrome P450 [CYP] 1A2 activity), 5-hydroxyomeprazole/omeprazole (CYP2C19 activity) and losartan/losartan carboxylic acid (CYP2C9 activity), and cross-sectionally compare these CYP-activities with normal-to-overweight controls. Methods: This trial included patients with severe obesity preparing for RYGB (n = 40) or diet-induced (n = 41) weight loss, and controls (n = 18). Both weight loss groups underwent a 3-week low-energy diet ( |
| Databáze: | OpenAIRE |
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