Investigation of the effect of astaxanthin on alveolar bone loss in experimental periodontitis
| Autor: | A. Lektemur Alpan, Fikret Gevrek, H. Balci Yuce, Hulya Toker |
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| Přispěvatelé: | [Yuce, H. Balci] Gaziosmanpasa Univ, Dept Periodontol, Fac Dent, Tokat, Turkey -- [Alpan, A. Lektemur] Pamukkale Univ, Dept Periodontol, Fac Dent, Denizli, Turkey -- [Gevrek, F.] Gaziosmanpasa Univ, Fac Med, Dept Histol & Embryol, Tokat, Turkey -- [Toker, H.] Cumhuriyet Univ, Dept Periodontol, Fac Dent, Sivas, Turkey, balci yuce, hatice -- 0000-0003-3574-9751, LEKTEMUR ALPAN, AYSAN -- 0000-0002-5939-4783 |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
alveolar bone loss antioxidant medicine.medical_treatment Bone Morphogenetic Protein 2 Cell Count Wistar rat Xanthophylls Antioxidants chemistry.chemical_compound 0302 clinical medicine Bax protein rat animal Tartrate-resistant acid phosphatase bcl-2-Associated X Protein biology nitric oxide synthase drug effect Osteoblast astaxanthin medicine.anatomical_structure antioxidants Biochemistry Osteocalcin osteoblast Periodontics protein Bax medicine.medical_specialty Alveolar Bone Loss/*prevention & control Animals Antioxidants/*pharmacology Bone Morphogenetic Protein 2/metabolism Disease Models Animal Nitric Oxide Synthase/metabolism Osteoblasts/drug effects Osteocalcin/metabolism Periodontitis/*drug therapy Rats Wistar Xanthophylls/pharmacology bcl-2-Associated X Protein/metabolism 03 medical and health sciences Osteoclast Astaxanthin Internal medicine medicine xanthophyll Ligature Periodontitis Dental alveolus experimental periodontitis Osteoblasts business.industry disease model inducible nitric oxide synthase 030206 dentistry medicine.disease 030104 developmental biology Endocrinology chemistry biology.protein tartrate-resistant acid phosphatase business metabolism |
| Popis: | WOS: 000419401200016 PubMed ID: 29044575 Background and ObjectiveAstaxanthin is a keto-carotenoid that has a strong antioxidant effect. The purpose of this study was to evaluate the effects of astaxanthin on alveolar bone loss and histopathological changes in ligature-induced periodontitis in rats. Material and methodsWistar rats were divided into four experimental groups: non-ligated (C, n=6); ligature only (L, n=6); ligature and astaxanthin (1mg/kg/day astaxanthin, AS1 group, n=8); ligature and astaxanthin (5mg/kg/day astaxanthin, AS5 group, n=8). Silk ligatures were placed at the gingival margin of lower first molars of the mandibular quadrant. The study duration was 11days and the animals were killed at the end of this period. Changes in alveolar bone levels were clinically measured and tissues were immunohistochemically examined, osteocalcin, bone morphogenic protein-2, inducible nitric oxide synthase, Bax and bcl-2 levels in alveolar bone and tartrate-resistant acid phosphatase-positive osteoclast cells, osteoblast and inflammatory cell counts were determined. ResultsAlveolar bone loss was highest in the L group and the differences among the L, AS1 and AS5 groups were also significant (P.05). ConclusionWithin the limits of this study, it can be suggested that astaxanthin administration may reduce alveolar bone loss by increasing osteoblastic activity and decrease osteoclastic activity in experimental periodontitis model. |
| Databáze: | OpenAIRE |
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