Origin, Regulation, and Fitness Effect of Chromosomal Rearrangements in the Yeast Saccharomyces cerevisiae
| Autor: | Ying-Xuan Zhu, Xing-Xing Tang, Yang Sui, Dao-Qiong Zheng, Lei Qi, Xue-Ping Wen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
chromosomal rearrangement DNA repair ved/biology.organism_classification_rank.species Saccharomyces cerevisiae Chromosomal rearrangement Genome Catalysis Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound S. cerevisiae 0302 clinical medicine Physical and Theoretical Chemistry Model organism Molecular Biology lcsh:QH301-705.5 Spectroscopy Genetics Whole genome sequencing biology ved/biology Organic Chemistry DNA replication General Medicine biology.organism_classification recombination Computer Science Applications 030104 developmental biology chemistry lcsh:Biology (General) lcsh:QD1-999 whole-genome sequencing 030217 neurology & neurosurgery DNA |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 786, p 786 (2021) |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Chromosomal rearrangements comprise unbalanced structural variations resulting in gain or loss of DNA copy numbers, as well as balanced events including translocation and inversion that are copy number neutral, both of which contribute to phenotypic evolution in organisms. The exquisite genetic assay and gene editing tools available for the model organism Saccharomyces cerevisiae facilitate deep exploration of the mechanisms underlying chromosomal rearrangements. We discuss here the pathways and influential factors of chromosomal rearrangements in S. cerevisiae. Several methods have been developed to generate on-demand chromosomal rearrangements and map the breakpoints of rearrangement events. Finally, we highlight the contributions of chromosomal rearrangements to drive phenotypic evolution in various S. cerevisiae strains. Given the evolutionary conservation of DNA replication and recombination in organisms, the knowledge gathered in the small genome of yeast can be extended to the genomes of higher eukaryotes. |
| Databáze: | OpenAIRE |
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