Effect of vasopressin 1b receptor blockade on the hypothalamic–pituitary–adrenal response of chronically stressed rats to a heterotypic stressor
| Autor: | Francesca Spiga, Mark Craighead, Louise R Harrison, Fiona Thomson, Stafford L. Lightman, Cliona P MacSweeney |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Restraint Physical Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Vasopressin Time Factors Endocrinology Diabetes and Metabolism Pituitary-Adrenal System Neuropeptide Adrenocorticotropic hormone Rats Sprague-Dawley chemistry.chemical_compound Endocrinology Adrenocorticotropic Hormone Corticosterone Internal medicine medicine Animals Chronic stress Sensitization Arginine vasopressin receptor 1B business.industry Rats medicine.anatomical_structure chemistry business Antidiuretic Hormone Receptor Antagonists hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Journal of Endocrinology. 200:285-291 |
| ISSN: | 1479-6805 0022-0795 |
| Popis: | Exposure to chronic restraint (CR) modifies the hypothalamic–pituitary–adrenal (HPA) axis response to subsequent acute stressors with adaptation of the response to a homotypic and sensitization of the response to a heterotypic stressor. Since vasopressin (AVP) activity has been reported to change during chronic stress, we investigated whether this was an important factor in HPA facilitation. We therefore tested whether vasopressin 1b receptor (AVPR1B) blockade altered the ACTH and corticosterone response to heterotypic stressors following CR stress. Adult male rats were exposed to CR, single restraint, or were left undisturbed in the home cage. Twenty-four hours after the last restraint, rats were injected with either a AVPR1B antagonist (Org, 30 mg/kg, s.c.) or vehicle (5% mulgofen in saline, 0.2/kg, s.c.) and then exposed to either restraint, lipopolysaccharide (LPS) or white noise. CR resulted in the adaptation of the ACTH and corticosterone response to restraint and this effect was not prevented by pretreatment with Org. Although we found no effect of CR on LPS-induced ACTH and corticosterone secretion, both repeated and single episodes of restraint induced the sensitization of the ACTH, but not corticosterone response to acute noise. Pretreatment with Org reduced the exaggerated ACTH response to noise after both single and repeated exposure to restraint. |
| Databáze: | OpenAIRE |
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