Silver Fir (Abies alba L.) Polyphenolic Extract Shows Beneficial Influence on Chondrogenesis In Vitro under Normal and Inflammatory Conditions
| Autor: | Mateja Sirše, Borut Štrukelj, Samo K. Fokter, Janja Zupan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Lipopolysaccharides
Antioxidant subchondral bone medicine.medical_treatment polifenoli Pharmaceutical Science Osteoarthritis Resveratrol Pharmacology Osteoarthritis Hip Analytical Chemistry chemistry.chemical_compound 0302 clinical medicine Drug Discovery vnetje Cells Cultured 0303 health sciences food and beverages Flow Cytometry Chemistry (miscellaneous) 030220 oncology & carcinogenesis Molecular Medicine medicine.symptom Quercetin mesenchymal stromal cells Abies stromalne celice Cell Survival udc:616.72-002 Inflammation Article lcsh:QD241-441 03 medical and health sciences lcsh:Organic chemistry chondrogenesis medicine Humans Physical and Theoretical Chemistry mesenchymal stem/stromal cells polyphenols 030304 developmental biology Cell Proliferation mesenchymal stem cells Plant Extracts Organic Chemistry Mesenchymal stem cell Mesenchymal Stem Cells Chondrogenesis medicine.disease hondrogeneza osteoartritis osteoarthritis chemistry Polyphenol inflammation mezenhimske matične celice |
| Zdroj: | Molecules, Vol 25, Iss 4616, p 4616 (2020) Molecules Molecules, vol. 25, no. 20, 4616, 2020. Volume 25 Issue 20 |
| ISSN: | 1420-3049 |
| Popis: | Several plant polyphenols have been shown to reduce osteoarthritis symptoms due to their antioxidant, anti-inflammatory and immunomodulatory properties. We investigated the effects of two different polyphenolic extracts (Belinal, Pycnogenol) and two different polyphenols (resveratrol, quercetin) on the chondrogenic potential of bone-derived mesenchymal stem/stromal cells (MSCs) from healthy donors and patients with osteoarthritis. Our main aim was to determine whether Belinal, a commercially available polyphenolic extract from silver fir (Abies alba L.) branches, has comparable chondrogenic potential with the other tested extract and the polyphenols under inflammatory and non-inflammatory conditions. In our study, Belinal promoted significantly greater chondrogenesis compared to the untreated (p = 0.0289) and resveratrol-treated (p = 0.0468) MSCs from patients with hip osteoarthritis under non-inflammatory conditions. Under inflammatory conditions, chondrogenesis was significantly enhanced for MSCs treated with Belinal compared to the control (p = 0.0483). The other extract and the polyphenols did not show any significant effects on chondrogenesis under non-inflammatory or inflammatory conditions. None of the tested extracts and polyphenols showed significant effects on chondrogenesis in healthy donors, under either non-inflammatory or inflammatory conditions. Our data show that Belinal can boost the chondrogenesis of MSCs derived from patients with osteoarthritis, under both non-inflammatory and inflammatory conditions. |
| Databáze: | OpenAIRE |
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