Phenylpropane as an Alternative Dearomatizing Unit of Indoles:Discovery of Inaequalisines A and B Using Substructure-Informed Molecular Networking
| Autor: | Gaëla Cauchie, Mehdi A. Beniddir, Guillaume Bernadat, Erwan Poupon, Brice Kumulungui, Jean-François Gallard, Justin J. J. van der Hooft, Elvis Otogo N’Nang, Pierre Champy, Pierre Le Pogam |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Indole test
010405 organic chemistry Stereochemistry Chemistry Bioinformatics Monoterpene Organic Chemistry Combined use Absolute configuration 010402 general chemistry 01 natural sciences Biochemistry Callichilia inaequalis 0104 chemical sciences Molecular networking Bioinformatica Substructure Life Science Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters, 22(15), 6077-6081 Organic Letters 22 (2020) 15 |
| ISSN: | 1523-7060 |
| Popis: | Inaequalisines A and B (1 and 2), the first examples of hybrid alkylated phenylpropane monoterpene indole alkaloids, were isolated from the roots of Callichilia inaequalis, guided by the combined use of molecular networking and substructure annotation. Their structures, including absolute configuration, were elucidated by spectroscopic methods and ECD calculations. A possible biosynthetic pathway for 1 and 2 was postulated. |
| Databáze: | OpenAIRE |
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