FTIR Spectroscopy Suggests a Revised Mode of Action for the Cationic Side-Chain Effect of Ionic Liquids
| Autor: | Christian Robben, Roland Kalb, Peter Rossmanith, Patrick Mester, Tom Grunert, Monika Ehling-Schulz, Anna Kristina Witte |
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| Rok vydání: | 2019 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Quantitative structure–activity relationship Ionic Liquids Quantitative Structure-Activity Relationship 010402 general chemistry 01 natural sciences chemistry.chemical_compound Bacterial Proteins Spectroscopy Fourier Transform Infrared Side chain Escherichia coli Fourier transform infrared spectroscopy Mode of action Alkyl chemistry.chemical_classification 010405 organic chemistry Cell Membrane Cationic polymerization Imidazoles General Chemistry General Medicine Combinatorial chemistry 0104 chemical sciences Anti-Bacterial Agents Quaternary Ammonium Compounds chemistry Ionic liquid Organic synthesis |
| Zdroj: | ACS combinatorial science. 21(2) |
| ISSN: | 2156-8944 |
| Popis: | Over the past decades, ionic liquids (ILs) have gained considerable attention from the scientific community because of their versatile and designable properties. As a result, there are numerous IL applications, not only in organic synthesis, catalysis, or extraction but also as active pharmaceutical ingredients or novel antimicrobials. While considerable effort has been put into developing quantitative structure-activity relationship (QSAR) models for IL toxicity prediction, little is known about their actual mode of action. In this study, Fourier transform infrared (FTIR) spectroscopy is used to monitor IL induced molecular responses directly at the cellular level. Investigation of the well-known cationic alkyl side-chain effect (increasing side-chain length leads to increasing toxicity) of imidazolium- and ammonium-based ILs on two bacterial pathogens, enteropathogenic Escherichia coli (EPEC) and methicillin-resistant Staphylococcus aureus (MRSA), surprisingly revealed two distinct modes of action. Contrary to prior models, it was only for [TMC |
| Databáze: | OpenAIRE |
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