Prognostic role of polyvascular involvement in patients with symptomatic peripheral artery disease
| Autor: | Luise Adam, Joern F Dopheide, Iris Baumgartner, M Khorrami Borozadi, Heinz Drexel, Mathias Kaspar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Arterial disease medicine.medical_treatment Coronary arteriosclerosis Renal function Disease medicine.disease Diabetes mellitus Internal medicine Epidemiology medicine Cardiology Smoking cessation In patient Cardiology and Cardiovascular Medicine business 610 Medicine & health |
| DOI: | 10.7892/boris.148778 |
| Popis: | Background Patients with peripheral artery disease (PAD) are at very high risk of future cardiovascular events. However, clinical experience suggests that PAD has a wide range of prognosis due to a different atherosclerotic extent with further vascular beds affected, i.e. coronary artery disease (CAD) and/ or cerebrovascular disease (CeVD). Purpose We hypothesized that patients with a polyvascular extent (+ CAD and/ or CeVD) of PAD have poorer prognosis compared to those with PAD alone. Methods Single center longitudinal observational study with 1380 symptomatic PAD patients over a period from 2009 to 2019 (mean observational time: 60±32 months). We related the atherosclerotic extent (PAD, +1 vascular region (+/− CAD or CeVD) (+1V), +2 vascular regions (+CAD and CeVD) (+2V) to all-cause and cardiovascular mortality as well as to cardiovascular event rate. Results Baseline demographics showed that polyvascular patients (+1V and +2V) were older, suffered more often from diabetes, hypertension, dyslipidemia and had more severe impairment of their kidney function (all p Conclusion PAD patients with a polyvascular involvement receive an adequate guideline conform treatment. Nevertheless, mortality is higher in this population. Conversely, our data suggest, that an intensified treatment for patients with PAD alone might help to avoid progression into a polyvascular disease and in consequence an increased mortality in this population. PAD polyvascular outcomes Funding Acknowledgement Type of funding source: None |
| Databáze: | OpenAIRE |
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