The effects of infusion of trieicosapentaenoyl-glycerol emulsion on extravascular lung water during myocardial ischemia and reperfusion in dogs
| Autor: | Toshimitsu Jikuhara, Tomohito Hamazaki, Yutaka Kimura, Shuji Kitashiro, Teruhiro Tamura, Toshiji Iwasaka, Tetsuro Sugiura, Toshio Izuoka |
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| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Cardiac index Hemodynamics Blood Pressure Myocardial Reperfusion Injury Pulmonary Edema Anterior Descending Coronary Artery Biochemistry Dogs Internal medicine medicine.artery medicine Animals Pulmonary wedge pressure Vein Ligation Lung Phospholipids Triglycerides business.industry Organic Chemistry Fatty Acids Cell Biology respiratory system Pulmonary edema medicine.disease Mean blood pressure medicine.anatomical_structure Anesthesia Pulmonary artery Extravascular Lung Water Cardiology Emulsions business |
| Zdroj: | Lipids. 32(1) |
| ISSN: | 0024-4201 |
| Popis: | To test the effects of eicosapentaenoic acid (EPA) infusion on pulmonary edema induced by coronary ligation and reperfusion, extravascular lung water (EVLW) was measured in situ by the thermal-dye double indicator dilution method in dogs. In the control group of five dogs, 30 mL of a 10% soybean oil emulsion was infused through a leg vein. One hour after infusion, the left anterior descending coronary artery below the first diagonal branch was ligated for 15 min and then reperfused for 30 min. In the EPA group, six dogs were similarly treated with an emulsion of a 10% trieicosapentaenoyl-glycerol (90% pure). EVLW, pulmonary capillary wedge pressure, mean pulmonary artery pressure, mean blood pressure, and cardiac index were measured before and 15 min after coronary ligation, and 15 min and 30 min after coronary reperfusion. There were no significant differences in the hemodynamic indices between the two groups. EVLW significantly increased up to two times of baseline during coronary ligation in the control group (P< 0.05) and more during reperfusion (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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