Potential unfavorable impacts of BDNF Val66Met polymorphisms on metabolic risks in average population in a longevous area
| Autor: | Hao Huang, Ze-Ping Lv, Hua-Yu Wu, Zhang-Ya Bian, Ling Huang, Rui-Xing Yin, Rui-Jing Gan, Cheng-Wu Liu, Qinghua Liang, Shang-Ling Pan, Jun-Hua Peng, Xiao-Ling Zhou, Yi Ding |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty China Genotype Offspring Population Longevity Blood Pressure Disease Overweight 03 medical and health sciences 0302 clinical medicine Metabolic Diseases Internal medicine Survivorship curve medicine Metabolic risks Ethnicity Humans Allele Polymorphism education Aged Aged 80 and over education.field_of_study Polymorphism Genetic business.industry Brain-Derived Neurotrophic Factor BDNF gene Middle Aged Lipid Metabolism Correlation 030104 developmental biology Endocrinology Blood pressure Female Geriatrics and Gerontology medicine.symptom business 030217 neurology & neurosurgery Research Article |
| Zdroj: | BMC Geriatrics |
| ISSN: | 1471-2318 |
| Popis: | Background Brain-derived neurotrophic factor (BDNF) has been implicated in cognitive performance and the modulation of several metabolic parameters in some disease models, but its potential roles in successful aging remain unclear. We herein sought to define the putative correlation between BDNF Val66Met and several metabolic risk factors including BMI, blood pressure, fasting plasma glucose (FPG) and lipid levels in a long-lived population inhabiting Hongshui River Basin in Guangxi. Methods BDNF Val66Met was typed by ARMS-PCR for 487 Zhuang long-lived individuals (age ≥ 90, long-lived group, LG), 593 of their offspring (age 60–77, offspring group, OG) and 582 ethnic-matched healthy controls (aged 60–75, control group, CG) from Hongshui River Basin. The correlations of genotypes with metabolic risks were then determined. Results As a result, no statistical difference was observed on the distribution of allelic and genotypic frequencies of BDNF Val66Met among the three groups (all P > 0.05) except that AA genotype was dramatically higher in females than in males of CG. The HDL-C level of A allele (GA/AA genotype) carriers was profoundly lower than was non-A (GG genotype) carriers in the total population and the CG (P = 0.009 and 0.006, respectively), which maintained in females, hyperglycemic and normolipidemic subgroup of CG after stratification by gender, BMI, glucose and lipid status. Furthermore, allele A carriers, with a higher systolic blood pressure, exhibited 1.63 folds higher risk than non-A carriers to be overweight in CG (OR = 1.63, 95% CI: 1.05 - 2.55, P = 0.012). Multiple regression analysis displayed that the TC level of LG reversely associated with BDNF Val66Met genotype. Conclusions These data suggested that BDNF 66Met may play unfavorable roles in blood pressure and lipid profiles in the general population in Hongshui River area which might in part underscore their poorer survivorship versus the successful aging individuals and their offspring. Electronic supplementary material The online version of this article (doi:10.1186/s12877-016-0393-0) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink