Protection of Mice from Lethal EndogenousCandida albicansInfection by Immunization withCandidaMembrane Antigen
| Autor: | Hideyo Yamaguchi, Shigeru Tansho, Kazutoh Takesako, Yasuo Ono, Shigeru Ab, Shigetoshi Mizutani |
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| Rok vydání: | 2002 |
| Předmět: |
Antigens
Fungal Ratón Prednisolone Immunology Colony Count Microbial Kidney Microbiology Immunocompromised Host Mice Antigen Virology Candida albicans medicine Endogenous Infection Animals health care economics and organizations Mycosis Mice Inbred BALB C biology Anti-Inflammatory Agents Non-Steroidal Candidiasis Membrane Proteins medicine.disease biology.organism_classification humanities Corpus albicans Specific Pathogen-Free Organisms Liver Immunization Female medicine.drug |
| Zdroj: | Microbiology and Immunology. 46:307-311 |
| ISSN: | 0385-5600 |
| DOI: | 10.1111/j.1348-0421.2002.tb02700.x |
| Popis: | The protective effects of immunization with Candida membrane antigen (CMA) on a systemic infection originating from intestinally colonized Candida albicans were examined. The colonization of orally inoculated C. albicans in the intestinal tract was established in BALB/c mice that had been concomitantly treated with oral doses of antibacterial drugs. In these animals, a systemic dissemination of C. albicans with fatal outcome was induced by a repeated dosing of prednisolone. In this endogenous infection model, the effects of immunization by CMA on the infection were examined. CMA-immunized mice showed a longer lifespan than unimmunized mice. The protective effect of CMA immunization in immunosuppressed mice was also measured by a decrease in body weight loss after treatment with prednisolone and in the number of viable Candida cells in the target organs, the kidneys and livers. However, the CFU of C. albicans in the intestinal tract was not significantly lowered. These results suggest that CMA immunization inhibited the dissemination of systemic Candida infection from the intestinal tract induced by treatment with prednisolone. |
| Databáze: | OpenAIRE |
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