Pulmonary Arterial Hypertension in Adults: Novel Drugs and Catheter Ablation Techniques Show Promise? Systematic Review on Pharmacotherapy and Interventional Strategies
| Autor: | Francesco Pelliccia, Darrin D'Agostino, Carlo Gaudio, Abdul M. Keylani, Salvatore Rosanio, Cesare Greco |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Genetics and Molecular Biology (all)
Endothelin Receptor Antagonists Guanylate Cyclase Humans Hypertension Pulmonary Phosphodiesterase 5 Inhibitors Prostaglandins Pulmonary Artery United States United States Food and Drug Administration Catheter Ablation Biochemistry Genetics and Molecular Biology (all) Immunology and Microbiology (all) Medicine (all) medicine.medical_specialty medicine.medical_treatment Perforation (oil well) lcsh:Medicine Catheter ablation Review Article Biochemistry General Biochemistry Genetics and Molecular Biology Pharmacotherapy Internal medicine medicine.artery medicine General Immunology and Microbiology business.industry lcsh:R Pulmonary artery catheter Pulmonary General Medicine medicine.disease Pulmonary hypertension Surgery Heart failure Hypertension Pulmonary artery Cardiology Cutting balloon business |
| Zdroj: | BioMed Research International, Vol 2014 (2014) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | This systematic review aims to provide an update on pharmacological and interventional strategies for the treatment of pulmonary arterial hypertension in adults. Currently US Food and Drug Administration approved drugs including prostanoids, endothelin-receptor antagonists, phosphodiesterase type-5 inhibitors, and soluble guanylate-cyclase stimulators. These agents have transformed the prognosis for pulmonary arterial hypertension patients from symptomatic improvements in exercise tolerance ten years ago to delayed disease progression today. On the other hand, percutaneous balloon atrioseptostomy by using radiofrequency perforation, cutting balloon dilatation, or insertion of butterfly stents and pulmonary artery catheter-based denervation, both associated with very low rate of major complications and death, should be considered in combination with specific drugs at an earlier stage rather than late in the progression of pulmonary arterial hypertension and before the occurrence of overt right-sided heart failure. |
| Databáze: | OpenAIRE |
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