Impact of HDAC inhibitors on dendritic cell functions
| Autor: | Marc Grégoire, Zinaida Peric, Béatrice Gaugler, Mohamad Mohty, Jihane Frikeche, Eolia Brissot |
|---|---|
| Přispěvatelé: | Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service d'Hématologie Clinique, Centre hospitalier universitaire de Nantes (CHU Nantes), Saas, Philippe |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
MESH: Inflammation
Cancer Research medicine.medical_specialty [SDV.IMM] Life Sciences [q-bio]/Immunology MESH: Organ Transplantation Biology Organ transplantation 03 medical and health sciences 0302 clinical medicine Immune system Transplantation Immunology Neoplasms Genetics medicine Animals Humans MESH: Animals MESH: Neoplasms MESH: Histone Deacetylase Inhibitors MESH: Transplantation Immunology Antigen-presenting cell Molecular Biology 030304 developmental biology HDAC inhibitors dendritic cells function Inflammation 0303 health sciences MESH: Humans MESH: Dendritic Cells Dendritic Cells Organ Transplantation Cell Biology Hematology Dendritic cell 3. Good health Histone Deacetylase Inhibitors Immunology [SDV.IMM]Life Sciences [q-bio]/Immunology Histone deacetylase 030215 immunology |
| Zdroj: | Experimental Hematology Experimental Hematology, Elsevier, 2012, 40 (10), pp.783-91. ⟨10.1016/j.exphem.2012.06.008⟩ Experimental Hematology, 2012, 40 (10), pp.783-91. ⟨10.1016/j.exphem.2012.06.008⟩ |
| ISSN: | 0301-472X |
| DOI: | 10.1016/j.exphem.2012.06.008⟩ |
| Popis: | International audience; Histone deacetylase inhibitors are presently used in the routine clinic treatment against cancers. Recent data have established that some of these treatments have potent anti-inflammatory or immunomodulatory effects at noncytotoxic doses that might be of benefit in immuno-inflammatory disorders or post-transplantation. At least some of these effects result from the ability of histone deacetylase inhibitors to modulate the immune system. Dendritic cells are professional antigen presenting cells that play a major role in this immune system. Data summarized in this review brings some novel information on the impact of histone deacetylase inhibitors on dendritic cell functions, which may have broader implications for immunotherapeutic strategies. |
| Databáze: | OpenAIRE |
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