Temporal changes in laboratory markers of survivors and non-survivors of adult inpatients with COVID-19

Autor: Hong Quan Zhu, Zhi Sheng Zou, Bin Zhong, Xiao Yan Liu, Hui Min Zuo, Song Mao Ouyang, Xin Chen, Yun Wei Rao, Ying Na Xie
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
Time Factors
Neutrophils
SARS-CoV − 2
030204 cardiovascular system & hematology
Gastroenterology
lcsh:Infectious and parasitic diseases
Fibrin Fibrinogen Degradation Products
Leukocyte Count
03 medical and health sciences
0302 clinical medicine
White blood cell
Internal medicine
Humans
Medicine
lcsh:RC109-216
Lymphocyte Count
Survivors
Mean platelet volume
Pandemics
Retrospective Studies
Prothrombin time
Inpatients
Clinical characteristics
medicine.diagnostic_test
biology
SARS-CoV-2
business.industry
Laboratory tests
COVID-19
Temporal changes
Middle Aged
C-Reactive Protein
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
Cystatin C
Absolute neutrophil count
biology.protein
Female
Base excess
Creatine kinase
Apolipoprotein A1
business
Procalcitonin
Biomarkers
Research Article
Zdroj: BMC Infectious Diseases
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-10 (2020)
ISSN: 1471-2334
Popis: Background Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2, and outbreaks have occurred worldwide. Laboratory test results are an important basis for clinicians to determine patient condition and formulate treatment plans. Methods Fifty-two thousand six hundred forty-four laboratory test results with continuous values of adult inpatients who were diagnosed with COVID-19 and hospitalized in the Fifth Hospital in Wuhan between 16 January 2020 and 18 March 2020 were compiled. The first and last test results were compared between survivors and non-survivors with variance test or Welch test. Laboratory test variables with significant differences were then included in the temporal change analysis. Results Among 94 laboratory test variables in 82 survivors and 25 non-survivors with COVID-19, white blood cell count, neutrophil count/percentage, mean platelet volume, platelet distribution width, platelet-large cell percentage, hypersensitive C-reactive protein, procalcitonin, D-dimer, fibrin (ogen) degradation product, middle fluorescent reticulocyte percentage, immature reticulocyte fraction, lactate dehydrogenase were significantly increased (P P P P Conclusions By the comprehensive usage of the laboratory markers with different temporal changes, patients with a high risk of COVID-19-associated death or progression from mild to severe disease might be identified, allowing for timely targeted treatment.
Databáze: OpenAIRE
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