Direct comparison of biological effectiveness of protons and alpha-particles of the same LET. II. Mutation induction at the HPRT locus in V79 cells
| Autor: | F. Ianzini, Dudley T. Goodhead, Mauro Belli, M. A. Tabocchini, Giustina Simone |
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| Rok vydání: | 1992 |
| Předmět: |
Genetics
Hypoxanthine Phosphoribosyltransferase Radiological and Ultrasound Technology Linear energy transfer Hamster Alpha particle Biology biology.organism_classification Alpha Particles Molecular biology Chinese hamster Cell Line Energy Transfer Cell culture Mutation (genetic algorithm) Mutation Relative biological effectiveness Animals Radiation Genetics Radiology Nuclear Medicine and imaging Mutation frequency Protons Relative Biological Effectiveness |
| Zdroj: | International journal of radiation biology. 61(5) |
| ISSN: | 0955-3002 |
| Popis: | Mutation induction at the hprt locus has been studied in V79-4 Chinese hamster cells irradiated with mono-energetic protons and alpha-particles with LET of 20.3 and 23 keV microns-1. The mutation frequency increased linearly with the dose for all the four radiation qualities investigated, so that effectiveness for mutation induction could be expressed by the slope of the relevant curve. This effectiveness did not significantly change with the small change in LET of each kind of particle, while sizeable differences were found between particles. Protons were more effective in mutation induction than alpha-particles with the same LET by a factor of about 2. This finding is similar to, although slightly larger than, the factors 1.5-1.8 found for inactivation of the same cells in the same series of experiments. |
| Databáze: | OpenAIRE |
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