Environmental Exposures during Puberty: Window of Breast Cancer Risk and Epigenetic Damage
| Autor: | Rama Natarajan, Tarik Benmarhnia, Stacey N. Doan, Cristal Resto, Jerneja Tomsic, Dana Aljaber, Christine Thai, Eric C. Dietze, Marta M. Jankowska, Jiue-An Yang, Veronica Jones, Alan Nunez, Tanya A. Chavez, Dawn Au, Angelica Sanchez, Robert D. Cardiff, Mayra Serrano, Christopher Sistrunk, Victoria L. Seewaldt, Jeannine S. McCune |
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| Rok vydání: | 2020 |
| Předmět: |
Health
Toxicology and Mutagenesis lcsh:Medicine Review Toxicology Epigenesis Genetic breast cancer risk 0302 clinical medicine Risk Factors Residence Characteristics 2.2 Factors relating to the physical environment Aetiology Cancer Pediatric 0303 health sciences Environmental Carcinogen Human studies 3. Good health 030220 oncology & carcinogenesis Female Contaminated air Disease Susceptibility environment Refined sugar Physiological Nutritional Status Breast Neoplasms Stress 03 medical and health sciences Breast cancer Effective interventions Genetic Stress Physiological Environmental health Breast Cancer medicine Humans Epigenetics Obesity 030304 developmental biology business.industry Prevention lcsh:R Puberty Public Health Environmental and Occupational Health Environmental Exposure medicine.disease Disadvantaged empowerment Psychological business Stress Psychological Epigenesis |
| Zdroj: | International journal of environmental research and public health, vol 17, iss 2 International Journal of Environmental Research and Public Health, Vol 17, Iss 2, p 493 (2020) International Journal of Environmental Research and Public Health |
| Popis: | During puberty, a woman’s breasts are vulnerable to environmental damage (“window of vulnerability”). Early exposure to environmental carcinogens, endocrine disruptors, and unhealthy foods (refined sugar, processed fats, food additives) are hypothesized to promote molecular damage that increases breast cancer risk. However, prospective human studies are difficult to perform and effective interventions to prevent these early exposures are lacking. It is difficult to prevent environmental exposures during puberty. Specifically, young women are repeatedly exposed to media messaging that promotes unhealthy foods. Young women living in disadvantaged neighborhoods experience additional challenges including a lack of access to healthy food and exposure to contaminated air, water, and soil. The purpose of this review is to gather information on potential exposures during puberty. In future directions, this information will be used to help elementary/middle-school girls to identify and quantitate environmental exposures and develop cost-effective strategies to reduce exposures. |
| Databáze: | OpenAIRE |
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