Effect of stobadine on lipid peroxidation in brain and heart after ischemia and reperfusion of the brain
| Autor: | I. Juranek, Lubica Horakova, A. Ziegelhoeffer, Svorad Štolc, O. Ondrejičková |
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| Rok vydání: | 1999 |
| Předmět: |
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medicine.medical_specialty Free Radicals Ischemia Femoral artery General Biochemistry Genetics and Molecular Biology Antioxidants Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Internal medicine medicine.artery Malondialdehyde medicine Animals General Pharmacology Toxicology and Pharmaceutics Rats Wistar chemistry.chemical_classification Glutathione Peroxidase biology Superoxide Dismutase Glutathione peroxidase Myocardium Brain General Medicine medicine.disease Rat brain Rats Endocrinology chemistry Biochemistry Ischemic Attack Transient Reperfusion Injury biology.protein Lipid Peroxidation Reperfusion injury Carbolines Signal Transduction |
| Zdroj: | Life sciences. 65(18-19) |
| ISSN: | 0024-3205 |
| Popis: | Stobadine (ST), a novel drug with pyridoindol structure, was recently found to prevent reperfusion injury in rat brain. The aim of the present study was to reveal whether ST may prevent peroxidative changes in the heart and brain that were triggered by postischemic reperfusion of the brain. In the brain, reperfusion significantly increased the contents of malondialdehyde (MDA) by 43.8 % and conjugated diens (CD) by 24.5% when compared with the end of ischemia. In the heart, contents of MDA and CD in reperfusion became elevated three fold and by 41.7 %, respectively, when comparing to the values at the end of ischemia. In the heart, no significant changes in activities of the superoxide dismutase (SOD) and glutathione peroxidase (GPx) induced by ischemia or reperfusion were detected. In contrast, reperfusion induced a slight decrease in GPx activity in the brain. In accordance with our previous results, an application of ST (2 mg/kg) to the femoral artery shortly prior to reperfusion of the ischemic brain, prevented significantly MDA and CD accumulation in brain. Nevertheless, ST was not able to prevent the brain-ischemia/reperfusion-induced elevation of MDA and CD contents in the heart. |
| Databáze: | OpenAIRE |
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