Evaluation of methods for the prediction of membrane spanning regions
| Autor: | Michael D. R. Croning, Rolf Apweiler, Steffen Möller |
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| Rok vydání: | 2002 |
| Předmět: |
Models
Molecular Statistics and Probability Protein Conformation Computational Biology Membrane Proteins Computational biology Biology Protein Sorting Signals Bioinformatics Biochemistry Transmembrane protein Computer Science Applications Computational Mathematics ComputingMethodologies_PATTERNRECOGNITION Membrane protein Databases as Topic Solubility Computational Theory and Mathematics Molecular Biology Topology (chemistry) Strengths and weaknesses Software |
| Zdroj: | Bioinformatics. 18:218-218 |
| ISSN: | 1367-4811 1367-4803 |
| Popis: | Motivation: A variety of tools are available to predict the topology of transmembrane proteins. To date no independent evaluation of the performance of these tools has been published. A better understanding of the strengths and weaknesses of the different tools would guide both the biologist and the bioinformatician to make better predictions of membrane protein topology. Results: Here we present an evaluation of the performance of the currently best known and most widely used methods for the prediction of transmembrane regions in proteins. Our results show that TMHMM is currently the best performing transmembrane prediction program. Contact: moeller@ebi.ac.uk; croning@ebi.ac.uk; apweiler@ebi.ac.uk |
| Databáze: | OpenAIRE |
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