Plasma brain natriuretic peptide concentrations and the risk of cardiovascular events and death in general practice
| Autor: | Kazuhiko Tanabe, Keizo Tsuchida |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Population Cardiovascular events Risk Factors Internal medicine Natriuretic Peptide Brain medicine Humans cardiovascular diseases Mortality education Stroke Aged Aged 80 and over education.field_of_study business.industry Hazard ratio Atrial fibrillation Middle Aged Prognosis medicine.disease Brain natriuretic peptide Confidence interval Death Cardiovascular Diseases Heart failure Cardiology Female Immunoradiometric Assay Cohort study General practice Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiology. 52:212-223 |
| ISSN: | 0914-5087 |
| Popis: | SummaryObjectivesThe plasma brain natriuretic peptide concentrations (brain natriuretic peptide (BNP) levels) have a prognostic value of mortality and morbidity in patients with chronic heart failure and in a community-based population. However, the prognostic value of BNP levels in outpatients of general practice is not well known. This study investigated the relations of BNP levels to cardiovascular events and death in general practice.MethodsThis study covered 3123 consecutive outpatients (mean age 59.3±15.3 years; 42% men). BNP levels were measured by immunoradiometric assay (Shionogi) in an occasional sample of each person.ResultsDuring a median follow-up of 5.5 years, 271 patients underwent a cardiovascular event (heart failure 65, coronary heart disease events 63, arrhythmia 26, stroke 96, others 21), 92 died from cardiovascular disease and 227 died from all causes. The patients were stratified into two groups based on a cut-off level of BNP (100pg/ml). A BNP level ≧100pg/ml was associated with a hazard ratio (95% confidence interval) of 4.6 (3.5–6.1) for cardiovascular events compared with a BNP |
| Databáze: | OpenAIRE |
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