Safety assessment of two strains and anti-obese effects on mice fed a high-cholesterol diet
| Autor: | Shilong Jiang, Yihong Bao, Mingruo Guo, Malina Kuerman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Streptococcus thermophilus Lactobacillus paracasei medicine.drug_class Antibiotic sensitivity Antibiotics Biophysics Diet High-Fat Biochemistry chemistry.chemical_compound Nitroreductase Mice medicine Animals Food science Obesity Molecular Biology biology Triglyceride Cholesterol Probiotics food and beverages Cell Biology biology.organism_classification medicine.disease Hemolysis Mice Inbred C57BL chemistry Anti-Obesity Agents |
| Zdroj: | Biochemical and biophysical research communications. 572 |
| ISSN: | 1090-2104 |
| Popis: | Previous study documented that Lactobacillus paracasei S0940 and Streptococcus thermophilus ldbm1 have obvious cholesterol-lowering abilities in vitro. In this study, the safety of two strains were evaluated by nitroreductase test, hemolysis test and antibiotic sensitivity test and to evaluate the cholesterol-reducing abilities in vivo. The results indicated that two strains did not exhibit nitroreductase activities and were ɤ-hemolytic on blood agar plates. Further, both strains did not represent a health risk by antibiotic sensitivity test, and significantly reduced serum and liver cholesterol and triglyceride levels of high fat-fed mice. Compared with the high-fat model group, administration of the strains to mice fed a high-cholesterol diet increased fecal water content and fecal cholesterol and significantly improved the intestinal microbiota, which indicating that Lactobacillus paracasei S0940 and Streptococcus thermophilus ldbm1 have a positive effect on reducing cholesterol levels and may be used in functional food. |
| Databáze: | OpenAIRE |
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