Presentation of Celiac Disease in Finnish Children Is No Longer Changing: A 50-Year Perspective
| Autor: | J K Visakorpi, Kalle Kurppa, Laura Kivelä, Markku Mäki, Katri Kaukinen, Marja-Leena Lähdeaho, Tarja Ruuska, Merja Ashorn, Heini Huhtala, Pauliina Hiltunen |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Anemia Autoimmunity Disease medicine.disease_cause Severity of Illness Index Severity of illness medicine Humans Child Finland Subclinical infection Retrospective Studies business.industry Incidence (epidemiology) Incidence Retrospective cohort study medicine.disease Celiac Disease Child Preschool Pediatrics Perinatology and Child Health Immunology Disease Progression Female Presentation (obstetrics) business Forecasting |
| Zdroj: | The Journal of pediatrics. 167(5) |
| ISSN: | 1097-6833 |
| Popis: | Objectives To chart trends in the presentation of celiac disease in a large cohort of Finnish children diagnosed over a period of 48 years. Study design Clinical and serologic data, severity of small-bowel mucosal damage, and presence of associated conditions were gathered from 596 children diagnosed with celiac disease in 1966-2013. The children were divided into 4 groups based on the year of diagnosis (before 1980, 1980-1999, 2000-2009, and 2010-2013), and the variables were compared between the periods. The incidence of celiac disease autoimmunity in 2001-2013 was calculated based on the number of new antibody-positive cases in each year. Results Age at diagnosis rose from median 4.3 years before 1980 to between 7.6 and 9.0 years in the later periods. The severity of clinical presentation, in general, became milder and poor growth less common during the entire study period of 50 years. Percentages of children with classical gastrointestinal presentation decreased, and those with atypical or subclinical presentation increased after the 1990s, these changes leveling off in 2000-2013. Similarly, the severity of small-bowel mucosal damage was milder after the 1990s. The incidence of celiac disease autoimmunity increased in the early 2000s but then fluctuated without a clear trend. There were no significant secular changes in sex distribution, presence of anemia, levels of celiac antibodies, or celiac disease-associated conditions. Conclusions The clinical and histologic presentation of celiac disease in children became milder, especially in the 1980s and 1990s. However, most of these changes have reached a plateau in recent years. |
| Databáze: | OpenAIRE |
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