Low but not moderate amounts of caffeine increase co-consumption of ethanol in C57BL/6J mice
Autor: | Jennifer N. Berry, Montana D. Jenkins, Melissa J. Evans |
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Rok vydání: | 2021 |
Předmět: |
Male
medicine.medical_specialty Elevated plus maze Alcohol Drinking Clinical Biochemistry Binge drinking Alcohol Stimulation Anxiety Toxicology C57bl 6j Biochemistry Open field Binge Drinking Elevated Plus Maze Test Mice Behavioral Neuroscience chemistry.chemical_compound Caffeine Internal medicine medicine Animals Biological Psychiatry Pharmacology Ethanol Behavior Animal business.industry Feeding Behavior Substance Withdrawal Syndrome Mice Inbred C57BL Disease Models Animal Endocrinology chemistry Female business Open Field Test |
Zdroj: | Pharmacology Biochemistry and Behavior. 208:173221 |
ISSN: | 0091-3057 |
Popis: | The increasingly popular combination of "energy drinks" containing high amounts of caffeine and alcohol has been shown to induce a stimulated, rather than sedated, state which may result in increased binge drinking and increased risk for alcohol-attributable accidents. We sought to examine consumption patterns of and withdrawal from alcohol and caffeine using a voluntary co-consumption animal model. Male and female adult C57BL/6J mice were given access to increasing doses of caffeine (0.01-0.05%) and/or alcohol (3-20%) in a two-bottle choice, intermittent access voluntary paradigm with fluid consumption recorded daily. Anxiety-like behavior during withdrawal was assessed via elevated plus maze or open field test in experiment 2. Increasing both alcohol and caffeine simultaneously in Experiment 1 resulted in no significant changes in co-consumption compared to mice given access to only alcohol or caffeine. Experiment 2 held caffeine concentration steady while slowly increasing alcohol content and resulted in mice consuming more alcohol when it was consumed in tandem with low dose caffeine. Both male and female mice consumed more caffeine when it was paired with alcohol; however, no significant differences were observed during withdrawal behavior. These results suggest that caffeine may dose-dependently positively influence alcohol consumption in mice and echo clinical literature suggesting that caffeine and alcohol together may result in a heightened state of stimulation and lead to further binge drinking. The intermittent access paradigm affords increased translational validity regarding investigations of alcohol and caffeine co-consumption and may be useful in identifying the neurobiological mechanisms concerning co-consumption of such substances. |
Databáze: | OpenAIRE |
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