Serotonin transporter promoter region polymorphisms do not influence treatment response to escitalopram in patients with major depression
| Autor: | Eduard Maron, Triin Eller, Veiko Vasar, Anu Tammiste, David J. Nutt, Andres Metspalu, Kristi Kallassalu |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Citalopram Young Adult Internal medicine mental disorders medicine Humans Escitalopram Pharmacology (medical) Promoter Regions Genetic Psychiatry Biological Psychiatry Depression (differential diagnoses) Serotonin transporter Psychiatric Status Rating Scales Serotonin Plasma Membrane Transport Proteins Pharmacology Analysis of Variance Depressive Disorder Major Chi-Square Distribution Polymorphism Genetic biology business.industry medicine.disease Psychiatry and Mental health Endocrinology Neurology Pharmacogenetics 5-HTTLPR biology.protein Antidepressive Agents Second-Generation Major depressive disorder Female Neurology (clinical) Serotonin business medicine.drug |
| Zdroj: | European Neuropsychopharmacology. 19:451-456 |
| ISSN: | 0924-977X |
| DOI: | 10.1016/j.euroneuro.2009.01.010 |
| Popis: | Several studies and meta-analyses have implicated a polymorphism in the promoter region of the serotonin transporter (5-HTT) gene, 5-HTTLPR in treatment outcomes of selective serotonin re-uptake inhibitors in patients with major depression. In this study we investigated the impact of 5-HTTLPR and a functional SNP rs25531 on the treatment outcomes to escitalopram in depressive patients. The study sample consisted of 135 outpatients with major depressive disorder (mean age 31.1+/-11.6 years, 68% females) treated with escitalopram 10-20 mg/day for 12 weeks. There were no significant associations between 5-HTT promoter region polymorphisms and response rate or mean change of depressive symptoms during escitalopram treatment. However we showed that patients carrying S allele of 5-HTTLPR may have increased risk for some side effects, including headache, induced by escitalopram medication. |
| Databáze: | OpenAIRE |
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