Early-Onset Neonatal Sepsis in the Era of Group B Streptococcal Prevention
| Autor: | Robert S. Baltimore, Sharon Huie, Anne Schuchat, Katherine L. O'Brien, James I. Meek |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Fetal Membranes Premature Rupture Pediatrics medicine.medical_specialty medicine.drug_class Antibiotics Drug Resistance Medical Records Group B Meningitis Bacterial Streptococcus agalactiae Sepsis Pregnancy Streptococcal Infections Ampicillin medicine Humans Sex Distribution Antibiotic prophylaxis Intensive care medicine Gram-Positive Bacterial Infections Cross Infection Neonatal sepsis business.industry Incidence (epidemiology) Infant Newborn Bacterial Infections Antibiotic Prophylaxis medicine.disease Connecticut Pediatrics Perinatology and Child Health Female Gram-Negative Bacterial Infections business Meningitis medicine.drug |
| Zdroj: | Pediatrics. 108:1094-1098 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.108.5.1094 |
| Popis: | Objective. To determine whether intrapartum antibiotic prophylaxis for neonatal group B streptococcal (GBS) disease has resulted in an increased rate of non-GBS or antibiotic-resistant early-onset invasive neonatal disease. Methods. Maternal and infant chart review of all infants with bacteria other than GBS isolated from blood or spinal fluid in 1996 through 1999 in 19 hospitals (representing 81% of in-state births to state residents) throughout Connecticut. Suspected cases were identified through clinical microbiology laboratory records or throughInternational Classification of Diseases, Ninth Revisioncodes when microbiology records were incomplete. Results. Ninety-four cases of non-GBS early-onset sepsis or meningitis were detected between 1996 and 1999. The rate of GBS-related early-onset infection (days 0–6 of life) dropped from 0.61/1000 to 0.23/1000 births, but the annual rate of non-GBS sepsis remained steady, ranging from 0.65 to 0.68/1000 during the surveillance period. There was an increase in the proportion of Escherichia coli infections that were ampicillin resistant between 1996 and 1998, but the proportion decreased. in 1999 Conclusion. There was no increase in the incidence of non-GBS early-onset neonatal infections between 1996 and 1999. Fluctuations in the annual incidence of E coliinfections, including ampicillin-resistant infections, suggest the need for continuation of surveillance in Connecticut and expansion to monitor larger populations. |
| Databáze: | OpenAIRE |
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