Significant HLA class I type associations with aromatic antiepileptic drug (AED)-induced SJS/TEN are different from those found for the same AED-induced DRESS in the Spanish population
| Autor: | Jesús Frías, Pedro Herranz, Ana Fiandor, Carlos González-Herrada, Jessica González-Ramos, Lucia Cachafeiro, Alberto M. Borobia, Francisco J. de Abajo, Teresa Bellón, Rafael Hernandez, Olga Laosa, Rosario Cabañas, Olga González, Miguel A. Moreno Hidalgo, Elena Ramírez, José L. Castañer, José Antonio Aramburu, Hoi Y. Tong, Victoria Lerma, Antonio J. Carcas |
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| Rok vydání: | 2016 |
| Předmět: |
Phenytoin
Adult Male medicine.medical_specialty Adolescent Genotype Genes MHC Class I Pharmacology Lamotrigine 030226 pharmacology & pharmacy Gastroenterology White People 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors Internal medicine Medicine Humans Genetic Predisposition to Disease Risk factor Child Aged Aged 80 and over Polymorphism Genetic business.industry Carbamazepine Odds ratio Middle Aged Genotype frequency Spain Child Preschool Stevens-Johnson Syndrome Drug Hypersensitivity Syndrome Phenobarbital Anticonvulsants Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Pharmacological research. 115 |
| ISSN: | 1096-1186 |
| Popis: | Aromatic antiepileptic drugs (AEDs) are among the drugs most frequently involved in severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms (DRESS). This study investigated the associations between the genetic polymorphisms of HLA class-I and AED-induced SCARs in the Spanish population. HLA class-I genotypes were determined in AED (phenytoin[PHT],lamotrigine[LTG],carbamazepine[CBZ],phenobarbital[PB])-induced SJS/TEN (n=15) or DRESS (n=12) cases included in the Spanish SCAR registry, PIELenRed. There were 3 control groups: (A)tolerant to a single AED, (B)tolerant to any AED, and (C)Spanish population controls. For SJS/TEN, concomitant HLA-A*02:01/Cw15:02 alleles were significantly associated with PHT-cases compared to control groups B and C [(B)odds ratio(OR):14.75, p=0.009;(C)OR:27.50, p |
| Databáze: | OpenAIRE |
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