A single injection of immature dendritic cells is able to induce antitumour response against a murine colon adenocarcinoma with a low apoptotic index
| Autor: | Tomasz Stoklosa, Ahmad Jalili, Adam Giermasz, Marek Jakóbisiak, Jakub Golab, Dominika Olszewska, Grzegorz M. Wilczynski |
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| Předmět: |
Cancer Research
Programmed cell death Pathology medicine.medical_specialty Time Factors Cell Transplantation medicine.medical_treatment Apoptosis DNA Fragmentation Biology Adenocarcinoma Mice Immune system medicine In Situ Nick-End Labeling Tumor Cells Cultured Animals Antigen-presenting cell Mice Inbred BALB C Follicular dendritic cells Granulocyte-Macrophage Colony-Stimulating Factor General Medicine Dendritic cell Immunotherapy Dendritic Cells Cell cycle Flow Cytometry Oncology Colonic Neoplasms Cancer research Disease Progression Interleukin-4 Cell Division |
| Zdroj: | ResearcherID Scopus-Elsevier Europe PubMed Central |
| Popis: | Dendritic cells can induce an immune response as competent antigen presenting cells. It has been reported that immature bone marrow derived dendritic cells are capable of inducing an immune response against tumours displaying significant apoptosis. It is still controversial, however whether immature dendritic cells can also induce an immune response against tumours with a low apoptotic index. C-26 adenocarcinoma cells were injected into the footpad of Balb/c mice. One million immature dendritic cells cultured in vitro using GM-CSF and IL-4 were injected into the tumour-bearing footpad on day 6 after tumour cell inoculation. Tumour volume was measured starting from day 5 after tumour cell inoculation. Mice were observed daily for survival. The growing tumours were characterized by a low apoptotic index. There was a statistically significant delay in the tumour growth and a significant prolongation of the survival time in DC treated group as compared with controls (p |
| Databáze: | OpenAIRE |
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