Safflower oil emulsion: single and multiple infusions with or without added heparin in normal human volunteers
| Autor: | William D. Leathem, Pitambar Somani, Anne L. Barlow |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male Fat Emulsions Intravenous Parenteral Nutrition 030309 nutrition & dietetics Linoleic acid Medicine (miscellaneous) Pharmacology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Vein Blood Coagulation Safflower Oil Triglycerides chemistry.chemical_classification 0303 health sciences Nutrition and Dietetics Cholesterol business.industry Heparin Body Weight Amino acid Parenteral nutrition medicine.anatomical_structure Clotting time chemistry Biochemistry Emulsion 030211 gastroenterology & hepatology Parenteral Nutrition Total business Energy Intake Oils medicine.drug |
| Zdroj: | Journal of Parenteral and Enteral Nutrition. 4:307-311 |
| ISSN: | 0148-6071 |
| DOI: | 10.1177/0148607180004003307 |
| Popis: | Intravenous hyperalimentation in chronically ill patients has become increasingly common in hospitalized patients. Total parenteral nutrition includes supply of carbohydrates, amino acids, and lipids. The safety of a new emulsion of safflower oil (Liposyn 10%) infused by peripheral vein was evaluated in 15 normal male volunteers. All subjects tolerated Liposyn infusion, with a low incidence of side effects, when given either as a single infusion or multiple daily infusions to provide 4% of daily caloric requirements in the form of linoleic acid for 5 consecutive days. In large doses, the lipid infusion was accompanied by a decrease in Lee-White clotting time in most subjects, and 1.5 to 2 U/ml of heparin added to the emulsion reversed this effect. Such mini doses of heparin also accelerated the breakdown and disappearance of triglycerides, with a resultant increase in serum free fatty acids and cholesterol. These data suggest that safflower oil emulsion can be used as a source of essential fatty acids for intravenous alimentation. It is also suggested that patients receiving lipid infusion should receive heparin to minimize risks associated with hypercoagulability of blood. |
| Databáze: | OpenAIRE |
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