Regulation of diamine oxidase expression by beta 2-adrenoceptors in normal and hypertrophic rat kidney
| Autor: | M. Alfonsina Desiderio, Angela Sessa, Antonio Perin |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
medicine.medical_specialty Adrenergic receptor Alpha (ethology) Kidney Cyclase chemistry.chemical_compound Theophylline Internal medicine Receptors Adrenergic beta medicine Animals Beta (finance) Molecular Biology Forskolin Colforsin Amine oxidase (copper-containing) Diamine oxidase activity Rats Inbred Strains Cell Biology Hypertrophy Adrenergic Agonists Rats Endocrinology chemistry Sympatholytics Amine Oxidase (Copper-Containing) Diamine oxidase Diterpenes |
| Zdroj: | Biochimica et biophysica acta. 845(3) |
| ISSN: | 0006-3002 |
| Popis: | The administration of preferential adrenergic receptor antagonists to uninephrectomized rats revealed the beta 2-adrenergic mediation in diamine oxidase activity increase that occurs in the remaining kidney undergoing compensatory hypertrophy. In fact, beta 1, beta 2- or beta 2, but not alpha 1-, alpha 2-, or beta 1-receptor-blocking agents prevented this enzyme enhancement. Further studies with adrenoceptor agonists, such as epinephrine (alpha 1, alpha 2, beta 1, beta 2), isoproterenol (beta 1, beta 2) or terbutaline (beta 2) showed that also in normal rat kidney diamine oxidase activity is under the control of catecholamine-beta 2-receptors through a mechanism that involves new synthesis of mRNA and protein. Theophylline, an inhibitor of phosphodiesterase, or forskolin, an activator of adenyl cyclase, increased diamine oxidase activity as does epinephrine or nephrectomy. Thus, catecholamine-triggered beta 2-receptors coupled to adenyl cyclase are involved in the regulation of diamine oxidase activity in normal and hypertrophic rat kidney. |
| Databáze: | OpenAIRE |
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