Smoking upregulates α4β2* nicotinic acetylcholine receptors in the human brain
| Autor: | W. Eschner, Frank Jessen, Marc Warnecke, Hans Herzog, Michael J. Reinhardt, Joern Schmaljohann, Alexis Joe, Thomas Klockgether, Martina Minnerop, Christian G. Schütz, Ullrich Wüllner, Daniela Gündisch |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Cerebellum media_common.quotation_subject Central nervous system Receptors Nicotinic Statistical parametric mapping Internal medicine medicine Humans media_common Acetylcholine receptor business.industry General Neuroscience Addiction Smoking Brain Human brain Middle Aged Up-Regulation Behavior Addictive Nicotinic agonist medicine.anatomical_structure Endocrinology Positron-Emission Tomography Brainstem business |
| Zdroj: | Neuroscience Letters. 430:34-37 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2007.10.011 |
| Popis: | The role of the alpha4beta2* nicotinic acetylcholine receptors (nAChR) in tobacco addiction in humans is largely unresolved. We visualized brain alpha4beta2* nicotinic acetylcholine receptors of smokers and non-smokers with positron emission tomography using 2-[(18)F]fluoro-3-(2(S)azetidinylmethoxy)pyridine, commonly known as 2-[(18)F]F-A-85380. The total brain distribution volume of 2-[(18)F]F-A-85380 was significantly increased in smokers. Statistical parametric mapping revealed that the most prominent regional differences of distribution volumes (DV) were found in cerebellum and brainstem with an increased uptake in smokers. The up-regulation of alpha4beta2* nAChR upon chronic nicotine exposure via tobacco smoking incorporates subcortical brain regions which may play an important role in nicotine addiction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect