Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis
| Autor: | Lucy Smyth, Andrea Mazzetti, Charles D. Pusey, Lorraine Harper, Donna Reidlinger, Gina Gregorini, William F. Clark, Pexivas Investigators Pexivas Investigators, Adeera Levin, Toshiko Ito-Ihara, Chen-Au Peh, Xavier Puéchal, Ulrich Specks, Carmel M. Hawley, Oliver Floßmann, Simon Carette, Alina Casian, Wojciech Szczeklik, Peter A. Merkel, Janak de Zoysa, Nader Khalidi, David Jayne, Samir Mehta, Biljana Brezina, Ron Wald, Michael Walsh, Luis Felipe Flores-Suárez, Carol A. McAlear, L. Guillevin, Louis Girard, Natalie Ives, Wladimir Szpirt, Vladimir Tesar, Elizabeth Broadhurst, Christian Pagnoux, Shouichi Fujimoto |
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| Přispěvatelé: | McMaster University [Hamilton, Ontario], Royal Adelaide Hospital [Adelaide Australia], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Miyazaki, McMaster University, St. Joseph’s Healthcare, Royal Berkshire Hospital, St. Michael's Hospital, University of British Columbia (UBC), Università degli Studi di Brescia [Brescia], Mount Sinai Hospital [Toronto, Canada] (MSH), Mayo Clinic [Rochester], Charles University [Prague] (CU), Instituto Nacional de Enfermedades Respiratorias [México, Mexico], University of Cambridge [UK] (CAM), Addenbrooke's Hospital, Cambridge University NHS Trust |
| Rok vydání: | 2020 |
| Předmět: |
MESH: Combined Modality Therapy
medicine.medical_specialty Cyclophosphamide medicine.medical_treatment Azathioprine 030204 cardiovascular system & hematology urologic and male genital diseases [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology Gastroenterology MESH: Dose-Response Relationship Drug MESH: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 03 medical and health sciences 0302 clinical medicine Maintenance therapy immune system diseases Internal medicine Medicine MESH: Incidence cardiovascular diseases 030212 general & internal medicine skin and connective tissue diseases Anti-neutrophil cytoplasmic antibody MESH: Aged MESH: Kidney Diseases MESH: Middle Aged MESH: Humans business.industry MESH: Cyclophosphamide MESH: Adult Glomerulonephritis General Medicine MESH: Plasma Exchange medicine.disease MESH: Induction Chemotherapy MESH: Male respiratory tract diseases 3. Good health MESH: Kidney Failure Chronic MESH: Administration Oral Rituximab Plasmapheresis MESH: Immunosuppressive Agents MESH: Rituximab MESH: Glucocorticoids business Vasculitis MESH: Female medicine.drug |
| Zdroj: | Walsh, M, Merkel, P A, Peh, C, Szpirt, W M, Puéchal, X, Fujimoto, S, Hawley, C M, Khalidi, N, Floßmann, O, Wald, R, Girard, L P, Levin, A, Gregorini, G, Harper, L, Clark, W F, Pagnoux, C, Specks, U, Smyth, L, Tesar, V, Ito-ihara, T, De Zoysa, J R, Szczeklik, W, Flores-suárez, L F, Carette, S, Guillevin, L, Pusey, C D, Casian, A L, Brezina, B, Mazzetti, A, Mcalear, C A, Broadhurst, E, Reidlinger, D, Mehta, S, Ives, N & Jayne, D R W 2020, ' Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis ', New England Journal of Medicine, vol. 382, no. 7, pp. 622-631 . https://doi.org/10.1056/NEJMoa1803537 New England Journal of Medicine New England Journal of Medicine, Massachusetts Medical Society, 2020, 382 (7), pp.622-631. ⟨10.1056/NEJMoa1803537⟩ |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejmoa1803537 |
| Popis: | BACKGROUND More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis. METHODS We conducted a randomized trial with a 2-by-2 factorial design to evaluate the use of plasma exchange and two regimens of oral glucocorticoids in patients with severe ANCA-associated vasculitis (defined by an estimated glomerular filtration rate of |
| Databáze: | OpenAIRE |
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