Comparison of HIV Type 1 RNA Plasma Viremia, p24 Antigenemia, and Unintegrated DNA as Viral Load Markers in Pediatric Patients
| Autor: | Louis D. Saravolatz, Charlene E. Bush, Odette Manzor, Flossie Cohen, Dwayne Baxa, Richard M. Donovan, Ellen Moore |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Virus Integration Immunology HIV Core Protein p24 HIV Infections Viremia Biology Virus Zidovudine Virology Immunopathology medicine Humans Child Sida Infant virus diseases RNA biology.organism_classification medicine.disease CD4 Lymphocyte Count Treatment Outcome Infectious Diseases Child Preschool DNA Viral HIV-1 RNA Viral Female Viral disease Viral load Biomarkers Follow-Up Studies medicine.drug |
| Zdroj: | AIDS Research and Human Retroviruses. 12:11-15 |
| ISSN: | 1931-8405 0889-2229 |
| Popis: | Better surrogate markers need to be developed to evaluate therapy in HIV-infected children. This study evaluated plasma RNA, immune complex-dissociated p24 antigenemia, and unintegrated DNA (uDNA) in HIV-infected pediatric patients. Ten children were followed from initiation of nucleoside antiretroviral therapy at intervals up to 24 months. Prior to initiation of therapy, HIV RNA was detected in 10 of 10 patients (median, 76,000 Eq/ml), p24 antigen was detected in 8 of 10 patients (median, 193 pg/ml), and uDNA was detected in 6 of 7 patients (median, 10% uDNA). After 12 months the RNA decreased in all patients and became undetectable in six. In contrast, p24 antigenemia decreased in 6 of 10 patients, remained undetectable in 1, and increased in 3. HIV uDNA decreased in six of six patients and became undetectable in three. There was no overall change in CD4 cell count. Plasma RNA and uDNA levels are both sensitive markers of nucleoside therapy in children; however, they do not covary strongly. |
| Databáze: | OpenAIRE |
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