Clinical Features of Patients with Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
| Autor: | Zheng Liu, Shimeng Liu, Xu-Xiang Zhang, Yaou Liu, Huiqing Dong, Si-Zhao Li, Hai Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Pathology lcsh:Medicine Gastroenterology 0302 clinical medicine Demyelinating disease Myelin Oligodendrocyte Glycoprotein Cerebrospinal Fluid biology medicine.diagnostic_test Neuromyelitis Optica Demyelinating Disease General Medicine Middle Aged Magnetic Resonance Imaging Original Article Female Aquaporin-4 Multiple Sclerosis Neuromyelitis Optica Spectrum Disorder Oligoclonal Bands Adult medicine.medical_specialty Adolescent Myelin oligodendrocyte glycoprotein 03 medical and health sciences Young Adult Internal medicine medicine Humans Autoantibodies Retrospective Studies Aquaporin 4 Neuromyelitis optica business.industry Multiple sclerosis lcsh:R Autoantibody Retrospective cohort study Magnetic resonance imaging medicine.disease 030104 developmental biology biology.protein Myelin-Oligodendrocyte Glycoprotein Differential diagnosis business 030217 neurology & neurosurgery Demyelinating Diseases |
| Zdroj: | Chinese Medical Journal Chinese Medical Journal, Vol 129, Iss 17, Pp 2079-2084 (2016) |
| ISSN: | 0366-6999 |
| Popis: | Background: Neuromyelitis optica spectrum disorder (NMOSD) was long believed to be an aggressive form of multiple sclerosis (MS). This study aimed to describe the clinical features of patients with MS and NMOSD to assist in differential diagnoses in clinical practice. Methods: Data including the patients' serum and cerebrospinal fluid (CSF) tests, image findings, and clinical information from 175 patients with MS or NMOSD at Xuanwu Hospital, Capital Medical University from November 2012 to May 2014 were collected and analyzed retrospectively. An enzyme-linked immunosorbent assay was performed to detect the myelin oligodendrocyte glycoprotein (MOG) autoantibodies in CSF and serum. Cell-based assays were used to detect aquaporin-4-antibody (AQP4-Ab). The Chi-square test was used to compare the categorical variables. Wilcoxon rank sum test was performed to analyze the continuous variables. Results: Totally 85 MS patients (49%) and 90 NMOSD patients (51%) were enrolled, including 124 (71%) women and 51 (29%) men. Fewer MS patients (6%) had autoimmune diseases compared to NMOSD (19%) (Δ2 = 6.9, P < 0.01). Patients with NMOSD had higher Expanded Disability Status Scale scores (3.5 [3]) than MS group (2 [2]) (Z = −3.69, P < 0.01). The CSF levels of white cell count and protein in both two groups were slightly elevated than the normal range, without significant difference between each other. Positivity of serum AQP4-Ab in NMOSD patients was higher than that in MS patients (MS: 0, NMOSD: 67%; Δ2 = 63.9, P < 0.01). Oligoclonal bands in CSF among NMOSD patients were remarkably lower than that among MS (MS: 59%, NMOSD: 20%; Δ2 = 25.7, P < 0.01). No significant difference of MOG autoantibodies was found between the two groups. Conclusion: The different CSF features combined with clinical, magnetic resonance imaging, and serum characteristics between Chinese patients with MS and NMOSD could assist in the differential diagnosis. |
| Databáze: | OpenAIRE |
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