Efeito da denervação renal na hipertrofia do ventrículo esquerdo de ratos hipertensos e seu mecanismo
| Autor: | Kan Yang, Lihua Tan, Xiaohong Tang, Xiaogang Li, Weihong Jiang, Yunzhong Guo |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Sympathetic Nervous System Blotting Western Blood Pressure Norepinefrina Kidney Left ventricular hypertrophy Rats Inbred WKY Sham group Norepinephrine (medication) Random Allocation Receptor 4 Toll-Like Norepinephrine Rats Inbred SHR Hipertrofia Ventricular Esquerda Internal medicine medicine Animals Ventricular remodeling Ratos Denervation Ventricular Remodeling Interleukin-6 Tumor Necrosis Factor-alpha business.industry Myocardium NF-kappa B Rim medicine.disease Immunohistochemistry Rats Toll-Like Receptor 4 Blood pressure medicine.anatomical_structure Ventricle Anesthesia Hypertension Remodelação Ventricular Linear Models Cardiology Hypertrophy Left Ventricular Surgery business Denervação medicine.drug |
| Zdroj: | Acta Cirúrgica Brasileira v.27 n.11 2012 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Volume: 27, Issue: 11, Pages: 815-820, Published: NOV 2012 |
| ISSN: | 0102-8650 |
| Popis: | PURPOSE: To investigate the effect of renal denervation (RDN) on the blood pressure, left ventricular hypertrophy and myocardial expression of TLR4/NF-κB in spontaneously hypertensive rats (SHR). METHODS: A total of 36 SHR were randomly assigned into control group (D0), RDN group (D) and sham group (S). 12 WKY rats of same age served as controls (WKY group). Rats in the D0 and WKY groups were sacrificed, but rats in the D and S group were sacrificed at one week and six weeks after surgery. The heart was collected and the left ventricle weighted followed by calculation of left ventricular mass index (LVMI). RESULTS: In the D0 group, the blood pressure, LVMI and protein expression of TLR4, NF-κB, TNF-α and IL-6 in the myocardium were markedly higher than that in the WKY group (p |
| Databáze: | OpenAIRE |
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