Population-based screening for selective immunoglobulin A (IgA) deficiency in Lithuanian children using a rapid antibody-based fingertip test
| Autor: | Vaidotas Urbonas, Kalle Kurppa, Rimante Cerkauskiene, Markku Mäki, Arvydas Kaminskas, Jolita Sadauskaite |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Immunoglobulin A Pediatrics medicine.medical_specialty Adolescent Population Physical examination Disease 030204 cardiovascular system & hematology Selective IgA deficiency Autoimmune Diseases 03 medical and health sciences 0302 clinical medicine Clinical Research Prevalence medicine Mass Screening Humans Child education Mass screening IgA Deficiency education.field_of_study biology medicine.diagnostic_test business.industry Lithuania General Medicine medicine.disease Confidence interval Early Diagnosis Point-of-Care Testing Immunology biology.protein Female 030211 gastroenterology & hepatology Antibody business |
| Zdroj: | Medical science monitor, Albertson : International Scientific Information, Inc., 2016, Vol. 22, p. 4773-4778 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1234-1010 1643-3750 |
| Popis: | BACKGROUND Selective immunoglobulin A (IgA) deficiency is the most common inherited immunodeficiency disorder worldwide. An early diagnosis is advocated because of the increased risk of infections, autoimmune diseases, and allergic reactions. We investigated the usefulness of a rapid point-of-care test in detecting for IgA deficiency in a population with a previously unknown prevalence. MATERIAL AND METHODS Altogether, 1000 children aged 11-13 years from randomly selected Lithuanian schools were enrolled. A point-of-care test with a fingertip sample was used to screen for the presence of IgA deficiency in children whose parents gave consent. Those with suspected IgA deficiency were referred to hospital for further clinical examination and confirmation of the diagnosis. In addition, their medical histories were compared with those of 30 age- and sex-matched healthy controls. RESULTS IgA deficiency was suspected in one girl and in three boys on the basis of the rapid test, and the diagnosis was confirmed for all four cases (prevalence 0.4%, 95% confidence interval 0.16-1.02%). There was no difference in disease history or complications between IgA-deficient children and healthy controls. CONCLUSIONS The rapid antibody test is a practical and accurate method to diagnose selective IgA deficiency in children. The prevalence of IgA deficiency among Lithuanian schoolchildren is 1:250. |
| Databáze: | OpenAIRE |
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