Association between gestational diabetes mellitus and periodontitis via the effect of reactive oxygen species in peripheral blood cells
| Autor: | Chatkoew Boriboonhirunsarn, Nattawan Bunpeng, Kallapat Tansriratanawong, Dittakarn Boriboonhirunsarn, Teerat Sawangpanyangkura |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases Pregnancy Risk Factors Diabetes mellitus medicine Humans Family history Risk factor Periodontitis Blood Cells business.industry Obstetrics nutritional and metabolic diseases Odds ratio medicine.disease female genital diseases and pregnancy complications Gestational diabetes Diabetes Gestational Cross-Sectional Studies Case-Control Studies Periodontics Female business Reactive Oxygen Species Body mass index |
| Zdroj: | Journal of periodontologyREFERENCES. 93(5) |
| ISSN: | 1943-3670 |
| Popis: | Background Periodontitis (P) has emerged as a risk factor for gestational diabetes mellitus (GDM) through immune cell function alterations, elevated proinflammatory mediators, and increased reactive oxygen species (ROS). The main objective of present study was to determine associations between pregnancy with and without GDM and P. The secondary objective was to compare ROS production in peripheral blood cells (PBCs) of pregnant women with and without GDM. Methods This cross-sectional case-control study included 128 pregnant women: 64 with and 64 without GDM. All participants were examined for clinical parameters of GDM and periodontal conditions. Associations between GDM-related periodontal data and GDM risk were evaluated by multiple logistic regression. PBCs were isolated and cultured. ROS productions in each PBCs types was investigated by flow cytometry with ROS antibodies. Results P was significantly more prevalent in pregnant women with GDM than in those without GDM (57.8% vs 37.5%), with an odds ratio (OR) of 2.28, and a 95% confidence interval (CI) of 1.12 to 4.64 (P = 0.022). The OR (95% CI) was 2.59 (1.19 to 5.65) (P = 0.017) after adjusting for potential confounding factors, including diabetes mellitus family history, age≥30 years, body mass index, and maternal age. ROS levels in all PBCs types were significantly higher in the GDM than in the non-GDM group (P Conclusion This study supported the association between P and GDM and indicated that P may be a risk factor for GDM. High levels of ROS production in the PBCs of pregnant women with GDM emphasized the association with GDM. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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