Correlation between pri-miR-124 (rs531564) polymorphism and congenital heart disease susceptibility in Chinese population at two different altitudes: a case-control and in silico study
| Autor: | Tao You, Wenke Yang, Dehong Li, Hongmiao Yu, Yuping Wei, Yunhan Ding, Kang Yi, Xiaodong Xie |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Heart Defects Congenital Male China Heart disease MiR-124 Health Toxicology and Mutagenesis In silico Single-nucleotide polymorphism 010501 environmental sciences Bioinformatics 01 natural sciences Polymorphism Single Nucleotide Hypoxemia Asian People Risk Factors medicine Environmental Chemistry SNP Humans Computer Simulation Genetic Predisposition to Disease Allele Hypoxia Gene Alleles 0105 earth and related environmental sciences Tetralogy of Fallot Congenital heart disease Aged business.industry Altitude General Medicine medicine.disease Pollution Single nucleotide polymorphism MicroRNAs Case-Control Studies Female medicine.symptom business Research Article |
| Zdroj: | Environmental Science and Pollution Research International |
| ISSN: | 1614-7499 0944-1344 |
| Popis: | The development of congenital heart disease (CHD) is a complicated process and affected by multiple environmental factors, as genetic factors, and the interactions among those factors. Previous studies have shown that intrauterine hypoxic environment exposure is a risk factor of CHD, but the genetic factors involved in the process are not clear. In this study, given that tetralogy of Fallot (TOF) is a CHD with hypoxemia as its primary pathophysiological manifestation, an in silico analysis was performed to reveal the relationship between potential target genes (miR-124) with the energy metabolism in non-syndromic TOF patients’ cardiomyocyte. Furthermore, the study investigated the correlation between the primary miR-124 (rs531564) polymorphism and CHD susceptibility in 432 sporadic patients and 450 controls from two different altitude provinces (city) in China. Our study indicated that the minor C allele of rs531564 correlated with reduced risk of CHD in the low altitude city. Besides, the C allele has elevated frequency in the high-altitude group. Therefore, our findings suggest that the minor C allele of rs531564 SNP may be involved in the reduction of the risk of CHD in a way that interacts with the intrauterine hypoxic environmental factors. Electronic supplementary material The online version of this article (10.1007/s11356-019-05350-4) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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