Urinary kallikrein excretion in idiopathic nephrotic syndrome
| Autor: | Ben H. Brouhard, Cunningham Rj, Luther B. Travis, Michael Berger, Petrusick T |
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| Rok vydání: | 1979 |
| Předmět: |
Male
medicine.medical_specialty Nephrotic Syndrome Urology Vasodilation Idiopathic Nephrotic Syndrome Excretion Internal medicine Medicine Humans cardiovascular diseases Child Kidney urogenital system business.industry Sodium Kallikrein medicine.disease biological factors Urinary Kallikrein Proteinuria Endocrinology medicine.anatomical_structure Amylases Potassium Kallikreins Minimal lesion business Nephrotic syndrome circulatory and respiratory physiology |
| Zdroj: | The Journal of urology. 121(5) |
| ISSN: | 0022-5347 |
| Popis: | The plasma kallikrein-kinin system, a potent vasodilator, has been implicated in causing the protein loss of the idiopathic nephrotic syndrome. However, the kidney possesses a kallikrein-kinin system separate from the plasma system. Thus, urinary kallikrein may reflect more accurately intrarenal events. Using a radiochemical esterolytic assay we measured the urinary kallikrein excretion in a patient with a minimal lesion nephrotic syndrome during relapse. Protein excretion was initially elevated (8.1 plus or minus 2.0 gm. per 24 hours) as was urinary kallikrein excretion (96.4 plus or minus 46.6 EU per 24 hours). After initiation of steroid therapy protein and kallikrein excretion decreased significantly (p less than 0.05). During the entire study kallikrein excretion was significantly correlated with protein excretion (r equals 0.89, p less than 0.01). It is tempting to speculate that activation of the intrarenal kallikrein-kinin system participates in the protein loss characteristic of the nephrotic syndrome. |
| Databáze: | OpenAIRE |
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