Obese female SHHF/Mcc-fa(cp) rats resist antihypertensive effects of renin-angiotensin system inhibition
| Autor: | Sylvia A. McCune, M. Judith Radin, Leslie C. Sharkey, Bethany J. Holycross, M. J. Radin |
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| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Time Factors Physiology Drug Resistance Tetrazoles Blood Pressure Plasma renin activity Rats Mutant Strains Renin-Angiotensin System Irbesartan Thinness Internal medicine Renin–angiotensin system Renin Internal Medicine Medicine Animals Obesity Antihypertensive Agents Sex Characteristics Angiotensin II receptor type 1 Dose-Response Relationship Drug business.industry Angiotensin II Biphenyl Compounds General Medicine Rats Blood pressure Endocrinology ACE inhibitor Female business Endothelin receptor medicine.drug |
| Zdroj: | Clinical and experimental hypertension (New York, N.Y. : 1993). 23(3) |
| ISSN: | 1064-1963 |
| Popis: | Gender and obesity may influence response to pharmacological modulation of the renin-angiotensin system. We used SHHF/Mcc-fa(cp) rats to study effect of obesity and gender on the ability of an AT1 receptor antagonist to decrease blood pressure. After 2 weeks treatment with irbesartan (50 mg/kg), only lean and obese males showed significant decreases in blood pressure, while obese females were completely resistant. Lean females showed a trend toward lowering of pressure (p=0.06). However, irbesartan similarly shifted angiotensin II dose response curves to the right in all groups. Twelve weeks of irbesartan also failed to decrease blood pressure, but did significantly reduce heart weight in obese females. In untreated rats, obese females had lower plasma renin activity and serum angiotensin converting enzyme activity compared to lean males, while lean and obese females had increased urinary endothelin excretion. Despite an otherwise similar genetic background contributing to hypertension and heart failure, obese females have different patterns of humoral activation compared to lean males, which may contribute to their resistance to the depressor effects of irbesartan. |
| Databáze: | OpenAIRE |
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